Gao Ya, Liu Xu, Gu Yan
The Third Central Hospital of Tianjin, Artificial Cell Engineering Technology Research Center, Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin, China.
Tianjin Nankai Hospital, Department of Science and Education, Tianjin, China.
J Med Biochem. 2025 Jun 13;44(3):568-575. doi: 10.5937/jomb0-53387.
The aim of the paper was to analyze the relationship between somatization in elderly patients with major depressive disorder (MDD) and brain-derived neurotrophic factor (BDNF), IL-6, IL-10, and TNF-a cognitive function, and sleep quality (SQ).
This was a case-control study on 80 elderly patients with MDD who were grouped based on the somatic self-rating scale (SSS) - the subjects with somatic symptoms (SS) as the AG and the subjects without SS as the BG. Additionally, 25 healthy volunteers from the same period were included as the control group (CG). The subjects' SQ scores, BDNF and its precursor (ProBDNF), and cognitive function scores were collected.
The SQ and SS scores of AG and BG were visibly higher than against CG, and those of AG were visibly higher in contrast to BG. The cognitive function scores of AG and BG were visibly lower than against CG, and the score of AG was lower than BG (P<0.05). There was a similarity in BDNF and ProBDNF levels between AG and BG (P>0.05). CRP, IL-6, IL-10, and TNF-a in both AG and BG were visibly higher as against CG; Those were visibly higher in AG as against BG (P<0.05). The SS scores of the patients suggested a visible negative correlation with cognitive function scores and an evident positive correlation with SQ scores.
Somatization symptoms may affect the SQ and cognitive function of people with depression, leading to an exacerbation of inflammatory responses; BDNF and ProBDNF levels may be more influenced by the overall state of depression rather than being determined solely by SS.
本文旨在分析老年重度抑郁症（MDD）患者的躯体化与脑源性神经营养因子（BDNF）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）、肿瘤坏死因子-α（TNF-α）、认知功能和睡眠质量（SQ）之间的关系。
这是一项针对80例老年MDD患者的病例对照研究，根据躯体自评量表（SSS）进行分组——有躯体症状（SS）的患者为AG组，无SS的患者为BG组。此外，纳入同期25名健康志愿者作为对照组（CG）。收集受试者的SQ评分、BDNF及其前体（ProBDNF）以及认知功能评分。
AG组和BG组的SQ和SS评分明显高于CG组，且AG组明显高于BG组。AG组和BG组的认知功能评分明显低于CG组，且AG组低于BG组（P<0.05）。AG组和BG组的BDNF和ProBDNF水平相似（P>0.05）。AG组和BG组的CRP、IL-6、IL-10和TNF-α均明显高于CG组；AG组明显高于BG组（P<0.05）。患者的SS评分与认知功能评分呈明显负相关，与SQ评分呈明显正相关。
躯体化症状可能影响抑郁症患者的SQ和认知功能，导致炎症反应加剧；BDNF和ProBDNF水平可能更多地受抑郁症整体状态的影响，而非仅由SS决定。
