Cancer Center, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China.
Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen 518055, China.
ACS Nano. 2024 Nov 12;18(45):31349-31359. doi: 10.1021/acsnano.4c10837. Epub 2024 Nov 1.
Bacterial pneumonia has garnered significant attention in the realm of infectious diseases owing to a surge in the incidence of severe infections coupled with the growing scarcity of efficacious therapeutic modalities. Antibiotic treatment is still an irreplaceable method for bacterial pneumonia because of its strong bactericidal activity and good clinical efficacy. However, the mucus layer forming after a bacterial infection in the lungs has been considered as the "Achilles' heels" facing the clinical application of such treatment. Herein, traceable biomimetic nanoantibiotics (BioNanoCFPs) were developed by loading indacenodithieno[3,2-]thiophene (ITIC) and cefoperazone (CFP) in nanoplatforms coated with natural killer (NK) cell membranes. The BioNanoCFP exhibited excellent demonstrated mucus-penetrating abilities, facilitating their arrival at the infection site. The presence of Toll-like receptors in the NK cell membrane rendered the BioNanoCFP with the capability to recognize pathogen-associated molecular patterns within bacteria, allowing precise targeting of bacterial colonization sites and achieving substantial therapeutic efficacy. Overall, our findings demonstrate the viability and desirability of using NK cell membrane-mediated drug delivery as a promising strategy for precision treatment.
细菌性肺炎在传染病领域引起了广泛关注，因为严重感染的发病率上升，而有效的治疗方法越来越稀缺。抗生素治疗仍然是细菌性肺炎的一种不可替代的方法，因为它具有很强的杀菌活性和良好的临床疗效。然而，肺部细菌感染后形成的黏液层被认为是这种治疗方法面临的“阿喀琉斯之踵”。在这里，通过在涂有自然杀伤 (NK) 细胞膜的纳米平台中装载吲哚并[3,2-b]噻吩（ITIC）和头孢哌酮（CFP），开发了可追踪的仿生纳米抗生素（BioNanoCFP）。BioNanoCFP 表现出优异的黏液穿透能力，使其能够到达感染部位。NK 细胞膜中 Toll 样受体的存在使 BioNanoCFP 能够识别细菌内的病原体相关分子模式，从而能够精确靶向细菌定植部位并实现显著的治疗效果。总的来说，我们的研究结果表明，使用 NK 细胞膜介导的药物传递作为一种有前途的精准治疗策略是可行和可取的。
