Deng Xiaoling, Zhuang Yu, Cui Jinjie, Wang Liyun, Zhan Huilu, Wang Xudong, Lin Kaili, Yuan Changyong
Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
School of Stomatology, Xuzhou Medical University, Affiliated Stomatological Hospital of Xuzhou Medical University, Xuzhou, 221004, China.
Adv Sci (Weinh). 2025 Aug 18:e10349. doi: 10.1002/advs.202510349.
Emerging piezoelectric biomaterials have demonstrated their huge potential in diverse medical applications, including ultrasound diagnosis and tissue regeneration. Human body possesses inherent piezoelectricity, producing electrical signal under endogenous load or external pressure to modulate cellular behaviors. Tissue defects caused by traumatic injury will disrupt the electrophysiological microenvironment of the injured area, resulting in unenviable self-healing. Triggered by physical activities or external stimulation, piezoelectric biomaterials exhibit a unique capability to generate electrical fields to restore the electrophysical microenvironment, reprogram cell fate and ultimately facilitate tissue repair. In this review, endogenous piezoelectric substances in the body and tissue piezoelectricity are introduced. Then, the characteristics and piezoelectricity of piezoelectric biomaterials in regenerative medicine are discussed, as well as strategies to prepare novel piezoelectric composites. Moreover, the molecular mechanisms for the piezoelectric effect on regulating tissue regeneration are systematically summarized. Recent advancements in piezoelectric biomaterials are comprehensively overviewed, including in the regeneration of bone, cartilage, skeletal muscles, tendon, skin, nerve, teeth and periodontal, myocardium, blood vessel and cornea tissues. Finally, the major challenges and future perspectives of piezoelectric biomaterials in regenerative medicine are proposed, hoping to boost the advancement in this promising scientific territory.
新兴的压电生物材料已在包括超声诊断和组织再生在内的多种医学应用中展现出巨大潜力。人体具有内在的压电性，在体内负荷或外部压力下会产生电信号来调节细胞行为。创伤性损伤导致的组织缺陷会破坏损伤区域的电生理微环境，导致不理想的自我修复。受身体活动或外部刺激触发，压电生物材料具有产生电场以恢复电物理微环境、重新编程细胞命运并最终促进组织修复的独特能力。在本综述中，介绍了体内的内源性压电物质和组织压电性。然后，讨论了压电生物材料在再生医学中的特性和压电性，以及制备新型压电复合材料的策略。此外，系统总结了压电效应调节组织再生的分子机制。全面概述了压电生物材料的最新进展，包括在骨、软骨、骨骼肌、肌腱、皮肤、神经、牙齿和牙周、心肌、血管和角膜组织再生方面的进展。最后，提出了压电生物材料在再生医学中的主要挑战和未来展望，希望推动这一有前景的科学领域的发展。
