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Lenke 1型和2型青少年特发性脊柱侧凸患者术后远端附加现象进展的危险因素

Risk factors for the progression of distal adding-on phenomenon after surgery in patients with Lenke type 1 and 2 adolescent idiopathic scoliosis.

作者信息

Li Tao, Li Yong, Wang Xiangbin, Long Yubin

机构信息

Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.

Department of Spinal Surgery, Shaoyang Central Hospital, Shaoyang, 422000, Hunan, China.

出版信息

Sci Rep. 2025 Aug 18;15(1):30237. doi: 10.1038/s41598-025-15714-1.

Abstract

To investigate risk factors associated with the progression of the distal adding-on phenomenon after posterior selective thoracic fusion in patients with Lenke type 1 and 2 adolescent idiopathic scoliosis (AIS). A retrospective analysis was conducted on 152 patients who underwent posterior selective thoracic fusion from December 2015 to December 2021. Among them, 48 patients experienced the distal adding-on phenomenon postoperatively. Based on whether this phenomenon progressed during follow-up, they were divided into progressive and non-progressive groups. Univariate analysis compared clinical and imaging data between the two groups, while multivariate logistic regression identified independent risk factors. Of the 48 patients with postoperative distal adding-on, 37 (77.1%) were non-progressive and 11 (22.9%) were progressive. Univariate analysis showed significant differences between the progressive and non-progressive groups in Risser sign grade (2.27 ± 1.10 vs. 3.73 ± 0.87, P < 0.001), number of segments between lowest instrumented vertebra (LIV) and the last substantially touched vertebra (LSTV) (-1.27 ± 0.79 vs. 0.51 ± 1.17, P < 0.001), preoperative clavicle angle (-2.55 ± 2.84 vs. -0.11 ± 2.82, P = 0.015), and preoperative trunk shift (21.05 ± 15.27 vs. 10.46 ± 13.32, P = 0.030). Multivariate analysis confirmed that lower Risser sign grade (OR = 0.16, 95% CI 0.03-0.82, P = 0.028) and fewer segments between LIV and LSTV (OR = 0.07, 95% CI 0.01-0.58, P = 0.013) were independent risk factors for the progression of the distal adding-on phenomenon. Lower skeletal maturity (Risser sign grade) and LIV located cephalad to LSTV are independent risk factors for the progression of the distal adding-on phenomenon in patients with Lenke type 1 and 2 AIS. For skeletally immature patients (Risser ≤ 3), LSTV should be preferentially chosen as LIV during surgery.

摘要

探讨Lenke 1型和2型青少年特发性脊柱侧凸(AIS)患者后路选择性胸段融合术后远端附加现象进展的相关危险因素。对2015年12月至2021年12月期间接受后路选择性胸段融合术的152例患者进行回顾性分析。其中,48例患者术后出现远端附加现象。根据该现象在随访期间是否进展,将他们分为进展组和非进展组。单因素分析比较两组的临床和影像学数据,多因素logistic回归确定独立危险因素。在48例术后出现远端附加现象的患者中,37例(77.1%)为非进展型,11例(22.9%)为进展型。单因素分析显示,进展组和非进展组在Risser征分级(2.27±1.10 vs. 3.73±0.87,P<0.001)、最低融合椎体(LIV)与最后一个实质性接触椎体(LSTV)之间的节段数(-1.27±0.79 vs. 0.51±1.17,P<0.001)、术前锁骨角(-2.55±2.84 vs. -0.11±2.82,P=0.015)和术前躯干偏移(21.05±15.27 vs. 10.46±13.32,P=0.030)方面存在显著差异。多因素分析证实,较低的Risser征分级(OR=0.16,95%CI 0.03-0.82,P=0.028)和LIV与LSTV之间较少的节段数(OR=0.07,95%CI 0.01-0.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9840/12361458/03d2b28d48d8/41598_2025_15714_Fig1_HTML.jpg

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