在猴模型中对人白细胞干扰素和成纤维细胞干扰素预防单纯疱疹病毒性角膜炎的比较评估。
Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model.
作者信息
Neumann-Haefelin D, Sundmacher R, Skoda R, Cantell K
出版信息
Infect Immun. 1977 Aug;17(2):468-70. doi: 10.1128/iai.17.2.468-470.1977.
Abstract
The prophylactic potency of topically applied human leukocyte interferon and human fibroblast interferon was compared in a monkey model with herpes simplex virus type 1-induced keratitis. Both interferons effectively prevented keratitis at 1.9 X 10(6) U of activity per ml but were ineffective at 1.9 X 10(3) U/ml. Slight differences between human leukocyte interferon and human fibroblast interferon observed at the level of 1.9 X 10(5) U/ml were not statistically significant.
摘要
在1型单纯疱疹病毒诱发角膜炎的猴模型中，比较了局部应用人白细胞干扰素和人成纤维细胞干扰素的预防效力。两种干扰素在每毫升1.9×10⁶活性单位时均能有效预防角膜炎，但在每毫升1.9×10³活性单位时无效。在每毫升1.9×10⁵活性单位水平观察到的人白细胞干扰素和人成纤维细胞干扰素之间的细微差异无统计学意义。
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本文引用的文献
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