Liu Yanyan, Ma Yuanyuan, Wang Lihong, Liu Congmei, Huang Xianghua, Zhang Jingkun
Department of Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Hebei Key Laboratory of Regenerative Medicine of Obstetrics and Gynecology, Shijiazhuang, China.
Tissue Eng Regen Med. 2025 Aug 19. doi: 10.1007/s13770-025-00754-5.
Infertility has a significant impact on women, affecting them both mentally and physically. Some of the current infertility-related diseases include intrauterine adhesions, endometriosis, polycystic ovary syndrome, primary ovarian insufficiency, and cancer. While existing treatments can help slow diseases progression and improve fertility for some patients, overall recovery rates remain low. The use of three-dimensional bioprinting (3D bioprinting) is becoming increasingly popular in clinical settings due to its high precision, customizable materials, and mechanical properties. In the state of infertility, its therapeutic potential is becoming more evident.
In this paper, we summarized the current treatment status of female infertility-related diseases, including cervical cancer, ovarian cancer, endometrial cancer, polycystic ovary syndrome, intrauterine adhesions, MRKH syndrome and other diseases, used databases such as PubMed, described the research progress and future development direction of 3D bioprinting in these diseases.
3D bioprinting technology could help repair damaged endometrial and ovarian tissue, and was able to create cell-loaded biological scaffolds to help restore the structure and function of affected organs. Furthermore, the development of organoids is opening new ways for research in regenerative medicine. It is expected that 3D bioprinting will not only be able to create organoid structures for research purposes but will also be utilized in clinical settings to effectively address infertility.
3D bioprinting is gaining popularity in the clinical field due to its high resolution, adjustable composition, and mechanical qualities. Infertility-related disorders damage women by inflicting a psychological and functional double blow. According to the current research, the application of 3D bioprinting technology to help patients restore fertility function has endless possibilities in the future.
不孕症对女性有重大影响，在心理和生理上都会影响她们。当前一些与不孕相关的疾病包括宫腔粘连、子宫内膜异位症、多囊卵巢综合征、原发性卵巢功能不全和癌症。虽然现有治疗方法可以帮助减缓某些患者疾病的进展并提高生育能力，但总体治愈率仍然较低。由于其高精度、可定制材料和机械性能，三维生物打印（3D生物打印）在临床环境中越来越受欢迎。在不孕症领域，其治疗潜力正变得越来越明显。
在本文中，我们总结了女性不孕相关疾病（包括宫颈癌、卵巢癌、子宫内膜癌、多囊卵巢综合征、宫腔粘连、MRKH综合征等疾病）的当前治疗状况，使用了如PubMed等数据库，描述了3D生物打印在这些疾病中的研究进展和未来发展方向。
3D生物打印技术可以帮助修复受损的子宫内膜和卵巢组织，并且能够创建负载细胞的生物支架来帮助恢复受影响器官的结构和功能。此外，类器官的发展为再生医学研究开辟了新途径。预计3D生物打印不仅能够创建用于研究目的的类器官结构，还将被应用于临床环境以有效解决不孕症问题。
3D生物打印因其高分辨率、可调节成分和机械特性在临床领域越来越受欢迎。与不孕相关的疾病通过造成心理和功能上的双重打击来损害女性。根据目前的研究，应用3D生物打印技术帮助患者恢复生育功能在未来有着无限可能。
