Album B, Olsen I, Lokken P
Int J Oral Surg. 1977 Jun;6(3):177-89. doi: 10.1016/s0300-9785(77)80051-3.
Twenty-four healthy patients undergoing two separate operations for removal of an impacted third molar from one or the other side of the mandible, were included in a double-blind crossover study. On the two occasions either oxyphenbutazone (Tanderil) or placebo was given for 5 days, commencing on the day before surgery. Plasma analyses confirmed drug intake. A number of objective and subjective assessments were recorded for a paired comparison of the postoperative course, including swelling, trismus, local temperature and pain. On the 1st, 3rd and 5th postoperative days after the oxyphenbutazone-operation, the measured swelling averaged 86, 85 and 83%, respectively, of that after the placebo-operation; the corresponding P-values were less than or equal to 0.11, 0.03 and 0.06. Oxyphenbutazone did not significantly reduce the local hyperpyrexia. It exerted, however, an excellent pain relief, which may have contributed to less trismus and patient preference for the course with this drug. The results obtained with this model in humans showed considerable discrepancies with the analgesic and anti-inflammatory effects ascribed to oxyphenbutazone from results in animal models. Side effects were mild and infrequent, and no unfavorable effects on bleeding or wound healing were noted. Routine use of oxyphenbutazone in oral surgery, however, is not recommended.
24名健康患者因下颌一侧或另一侧的阻生第三磨牙接受了两次单独手术，这些患者被纳入一项双盲交叉研究。在这两次手术中，从手术前一天开始，给予羟基保泰松（坦度尔）或安慰剂，持续5天。血浆分析证实了药物摄入。记录了一些客观和主观评估指标，用于对术后过程进行配对比较，包括肿胀、牙关紧闭、局部温度和疼痛。在羟基保泰松手术术后第1天、第3天和第5天，测得的肿胀平均分别为安慰剂手术后肿胀的86%、85%和83%；相应的P值分别小于或等于0.11、0.03和0.06。羟基保泰松并没有显著降低局部发热。然而，它具有出色的止痛效果，这可能是导致牙关紧闭减轻以及患者更倾向于使用该药物治疗过程的原因。在人体中使用该模型获得的结果与动物模型中归因于羟基保泰松的镇痛和抗炎作用存在相当大的差异。副作用轻微且不常见，未观察到对出血或伤口愈合的不利影响。然而，不建议在口腔手术中常规使用羟基保泰松。
