Spracklen Timothy F, Ndengane Mthawelanga, Butters Claire, Kaforou Myrsini, Zühlke Liesl J, Levin Michael, Webb Kate
From the Department of Paediatrics and Child.
Department of Medicine, Cape Heart Institute, University of Cape Town, Cape Town, South Africa.
Pediatr Infect Dis J. 2025 Aug 6. doi: 10.1097/INF.0000000000004926.
Multisystem inflammatory syndrome in children (MIS-C) is a severe response to SARS-CoV-2 that affects a small proportion of children. Overexpression of a nonspecific T cell receptor beta variable 11-2 in multiple populations has led to the hypothesis of a superantigen response underlying MIS-C. Here, we describe T cell receptor beta variable 11-2 expansion in South African children with MIS-C, supporting a common pathogenesis of MIS-C regardless of location.
儿童多系统炎症综合征（MIS-C）是对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的一种严重反应，影响一小部分儿童。多种人群中非特异性T细胞受体β可变区11-2的过表达导致了MIS-C潜在超抗原反应的假说。在此，我们描述了南非MIS-C儿童中T细胞受体β可变区11-2的扩增，支持了无论地理位置如何，MIS-C都有共同发病机制的观点。
