Nong Chaocao, Lin Haodong
Trauma Center, Affiliated First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, P. R. China.
Department of Orthopedics, Jiading Branch of Affiliated First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201803, P. R. China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2025 Aug 15;39(8):1061-1067. doi: 10.7507/1002-1892.202505083.
To review recent research progress in the use of auxiliary components of nerve conduits for the treatment of peripheral nerve injuries.
An extensive review of recent domestic and international literature was conducted to evaluate the role of auxiliary components in nerve conduits for peripheral nerve repair, with a focus on their effects and underlying mechanisms.
By incorporating auxiliary components such as bioactive molecules, therapeutic cells, and their derivatives, nerve conduits can create a more biomimetic regenerative microenvironment. This is achieved by providing neurotrophic support, modulating the immune microenvironment, improving blood and oxygen supply, and offering directional guidance for nerve regeneration. Consequently, the nerve conduit is transformed from a simple physical scaffold into an active, bio-functional repair system, which enhances the effectiveness for PNI.
While nerve conduits augmented with auxiliary components demonstrate improved effectiveness, further advancements are required in drug delivery systems and the integration of cellular components. Moreover, most current studies are based on animal or experiments. Randomized controlled clinical trials are necessary to validate their clinical effectiveness.
综述神经导管辅助成分在治疗周围神经损伤方面的最新研究进展。
广泛查阅国内外近期文献，评估辅助成分在周围神经修复神经导管中的作用，重点关注其效果及潜在机制。
通过纳入生物活性分子、治疗性细胞及其衍生物等辅助成分，神经导管可营造更具仿生学的再生微环境。这通过提供神经营养支持、调节免疫微环境、改善血液和氧气供应以及为神经再生提供定向引导来实现。因此，神经导管从一个简单的物理支架转变为一个活跃的、具有生物功能的修复系统，从而提高了周围神经损伤的治疗效果。
虽然添加辅助成分的神经导管显示出更好的疗效，但在药物递送系统和细胞成分整合方面仍需进一步改进。此外，目前大多数研究基于动物实验。需要进行随机对照临床试验来验证其临床疗效。
