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Linking phospholipid metabolism to septic cardiomyopathy via HIF-1α overactivation.

作者信息

Kayki Mutlu Gizem, Koch Walter J

机构信息

Department of Pharmacology, Faculty of Pharmacy, Ankara University, Ankara, Türkiye.

Department of Surgery, Division of Cardiovascular and Thoracic Surgery, Duke Cardiovascular Research Center, Duke University School of Medicine, Durham, NC, USA.

出版信息

Nat Cardiovasc Res. 2025 Aug 19. doi: 10.1038/s44161-025-00680-8.

DOI:10.1038/s44161-025-00680-8
PMID:40830232
Abstract
摘要

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本文引用的文献

1
Sepsis: the evolution of molecular pathogenesis concepts and clinical management.脓毒症：分子发病机制概念的演变与临床管理
MedComm (2020). 2025 Feb 23;6(3):e70109. doi: 10.1002/mco2.70109. eCollection 2025 Mar.
2
The lipid biology of sepsis.脓毒症的脂质生物学。
J Lipid Res. 2021;62:100090. doi: 10.1016/j.jlr.2021.100090. Epub 2021 Jun 1.
3
Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1.蛋白激酶A依赖性磷酸化刺激缺氧诱导因子1的转录活性。
Sci Signal. 2016 May 31;9(430):ra56. doi: 10.1126/scisignal.aaf0583.
4
Unfavourable consequences of chronic cardiac HIF-1α stabilization.慢性心脏 HIF-1α 稳定的不良后果。
Cardiovasc Res. 2012 Apr 1;94(1):77-86. doi: 10.1093/cvr/cvs014. Epub 2012 Jan 18.
5
A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis.TAK-242 治疗严重脓毒症的随机、双盲、安慰剂对照试验。
Crit Care Med. 2010 Aug;38(8):1685-94. doi: 10.1097/CCM.0b013e3181e7c5c9.
6
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha.核因子-κB通过对缺氧诱导因子-1α的转录调控将天然免疫与缺氧反应联系起来。
Nature. 2008 Jun 5;453(7196):807-11. doi: 10.1038/nature06905. Epub 2008 Apr 23.
7
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload.p53诱导的Hif-1抑制在压力过载期间导致心脏功能障碍。
Nature. 2007 Mar 22;446(7134):444-8. doi: 10.1038/nature05602. Epub 2007 Mar 4.
8
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.缺氧诱导因子-1通过积极下调线粒体氧消耗来介导对缺氧的适应。
Cell Metab. 2006 Mar;3(3):187-97. doi: 10.1016/j.cmet.2006.01.012.
9
Cytopathic hypoxia in sepsis.脓毒症中的细胞病变性缺氧
Acta Anaesthesiol Scand Suppl. 1997;110:87-95. doi: 10.1111/j.1399-6576.1997.tb05514.x.