Hemmerling Melissa, Schütte Sabrina, Eberhard Sveja, van Baal Katharina, Stiel Stephanie, Stahmeyer Jona Theodor
Department for Health Services Research, AOK Lower Saxony, Hildesheimer Str. 273, 30519, Hannover, Germany.
Institute for General Practice and Palliative Care, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Health Econ Rev. 2025 Aug 20;15(1):70. doi: 10.1186/s13561-025-00604-z.
Palliative care (PC) aims at improving the quality of life of patients suffering from life-threatening and life-limiting illnesses. International studies have found that PC is not only helpful for controlling symptoms and reducing hospital stays at the end of life, but also associated with reduced healthcare costs. However, evidence on the economic implications of outpatient PC in Germany is scarce. Accordingly, the current study aimed at assessing the impact of outpatient PC on end-of-life costs, and measuring differences between cancer and non-cancer patients who did and did not receive outpatient PC.
The study involved a retrospective, cross-sectional analysis of statutory health insurance data for individuals who died in 2019 and were older than 18 years at the time of death (34,012 individuals). To explore the impact of outpatient PC on end-of-life costs, three groups were formed: (1) all individuals, (2) individuals with a cancer diagnosis and (3) individuals with no cancer diagnosis. The data were analysed descriptively and linear regression models were conducted.
The descriptive results showed in the group of all individuals, patients receiving outpatient PC had higher costs in all healthcare sectors compared to those who did not receive outpatient PC. Cancer patients receiving outpatient PC had higher total healthcare costs (outpatient PC: 34,822€; no outpatient PC: 26,343€; p < 0.001) but lower hospital costs (outpatient PC: 17,485€; no outpatient PC: 18,713€; p = 0,004). Non-cancer patients receiving outpatient PC had similar total healthcare costs (p = 0.174) but lower hospital costs (outpatient PC: 11,505€; no outpatient PC: 12,667€; p = 0.001). The regression models showed significantly higher total healthcare costs (p < 0.001), outpatient physician costs (p < 0.001) and pharmaceutical costs (p < 0.001) for patients receiving outpatient PC in all groups. Also across all groups, hospital costs were similar between patients who were and were not receiving outpatient PC (all patients: + 40€, p = 0.808; cancer patients: -580€, p = 0.072; non-cancer patients: + 301€, p = 0.166).
Unlike the findings of international studies, the present study found that outpatient PC is not associated with lower end-of-life costs. The results for hospital costs were heterogeneous, but there was a trend towards lower costs for cancer patients receiving outpatient PC. Comparability with (inter)national studies remains difficult because financing systems and access to healthcare services are not internationally consistent. Many studies recommend the early integration of PC. Further analyses should investigate the connection between the time of initiating PC and end-of-life costs.
The main study was registered in the German Clinical Trials Register (Registration N° DRKS00024785; date of registration 6th May 2021).
姑息治疗(PC)旨在提高患有危及生命和限制生命疾病患者的生活质量。国际研究发现,姑息治疗不仅有助于控制症状和减少临终时的住院时间,还与降低医疗成本相关。然而,关于德国门诊姑息治疗的经济影响的证据很少。因此,本研究旨在评估门诊姑息治疗对临终成本的影响,并衡量接受和未接受门诊姑息治疗的癌症患者与非癌症患者之间的差异。
该研究对2019年死亡且死亡时年龄超过18岁的个人(34012人)的法定健康保险数据进行了回顾性横断面分析。为了探讨门诊姑息治疗对临终成本的影响,分为三组:(1)所有个体,(2)患有癌症诊断的个体,(3)没有癌症诊断的个体。对数据进行了描述性分析,并进行了线性回归模型分析。
描述性结果显示,在所有个体组中,接受门诊姑息治疗的患者在所有医疗领域的费用均高于未接受门诊姑息治疗的患者。接受门诊姑息治疗的癌症患者的总医疗费用较高(门诊姑息治疗:34822欧元;无门诊姑息治疗:26343欧元;p<0.001),但住院费用较低(门诊姑息治疗:17485欧元;无门诊姑息治疗:18713欧元;p=0.004)。接受门诊姑息治疗的非癌症患者的总医疗费用相似(p=0.174),但住院费用较低(门诊姑息治疗:11505欧元;无门诊姑息治疗:12667欧元;p=0.001)。回归模型显示,所有组中接受门诊姑息治疗的患者的总医疗费用(p<0.001)、门诊医生费用(p<0.001)和药品费用(p<0.001)显著更高。同样在所有组中,接受和未接受门诊姑息治疗的患者的住院费用相似(所有患者:+40欧元,p=0.808;癌症患者:-580欧元,p=0.072;非癌症患者:+301欧元,p=0.166)。
与国际研究结果不同,本研究发现门诊姑息治疗与降低临终成本无关。住院费用的结果存在异质性,但接受门诊姑息治疗的癌症患者有成本降低的趋势。由于融资系统和获得医疗服务的机会在国际上不一致,与(国际)研究的可比性仍然困难。许多研究建议早期整合姑息治疗。进一步的分析应调查开始姑息治疗的时间与临终成本之间的联系。
主要研究已在德国临床试验注册中心注册(注册号DRKS00024785;注册日期2021年5月6日)。