Burling T A, Stitzer M L, Bigelow G E, Mead A M
Addict Behav. 1985;10(3):319-23. doi: 10.1016/0306-4603(85)90014-0.
Factors which effect the expired air carbon monoxide (CO) levels of smokers were examined in matched subject pairs who smoked an equal number of daytime cigarettes but had different CO levels (mean difference = 15.4 ppm). Measures of puff number, duration, and spacing, as well as the amount of CO increase per cigarette (CO boost), were assessed while subjects smoked a single cigarette in daily laboratory sessions. Subjects with relatively high CO levels had larger increases in CO after smoking a single cigarette than did individuals with low CO levels (p. less than .005) but did not differ on any other smoking topography measure. These data suggest that simple topography measures of puff number and duration may not contribute to between subject differences in tobacco smoke exposure, and that greater attention should be given to more refined measures such as puff volume and depth of inhalation. These data also suggest that the measurement of CO boost per cigarette may provide useful information regarding tobacco smoke intake.
在配对的研究对象中，对影响吸烟者呼出气体中一氧化碳（CO）水平的因素进行了研究。这些配对对象每天吸同样数量的香烟，但CO水平不同（平均差异为15.4 ppm）。在每日的实验室环节中，当研究对象吸一支香烟时，对其抽吸次数、持续时间、间隔时间以及每支香烟的CO增加量（CO提升量）进行了评估。与CO水平较低的个体相比，CO水平相对较高的研究对象在吸一支香烟后CO的增加量更大（p值小于0.005），但在其他任何吸烟形态学指标上并无差异。这些数据表明，抽吸次数和持续时间等简单的形态学指标可能不会导致研究对象之间烟草烟雾暴露的差异，而应更多地关注诸如抽吸量和吸入深度等更精细的指标。这些数据还表明，测量每支香烟的CO提升量可能会提供有关烟草烟雾摄入量的有用信息。
