Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA 19104-3309, USA.
Exp Clin Psychopharmacol. 2009 Dec;17(6):405-12. doi: 10.1037/a0017649.
Filter vent blocking on best-selling light cigarettes increases smoke yield during standard machine testing but not in clinical investigations of smokers. The purpose of the study was to investigate the effect of (a) manipulating cigarette filter vent blocking and (b) blocking status of first cigarette of the day on carbon monoxide (CO) boost. Participants (n = 25; Marlboro Lights nonmenthol cigarette smokers, age range 21-60 years, minimum 15 daily cigarettes, and daily smoking for a minimum 5 years) completed the laboratory-based, within-subject, double-blind, cross-over design of 2 smoking sessions, one utilizing a smoking topography device, one without. Each session consisted of smoking 4 cigarettes; 2 with filter vents blocked and 2 with filter vents unblocked. Spent first daily cigarette filters collected between sessions were scored for evidence of filter vent blocking. Smoking cigarettes with blocked filter vents significantly increased CO boost in both laboratory sessions (p < .001). Those who blocked their first cigarette of the day (n = 10) had significantly greater CO boost when smoking a blocked cigarette, in relation to smoking an unblocked cigarette and in comparison with nonblockers (p = .04). Total puff volume was a significant predictor of CO boost when smoking unblocked and blocked cigarettes (ps < .04). Blocking filter vents significantly increased smoke exposure in relation to when filter vents are not blocked, particularly for those who block filter vents on their first cigarette of the day. Total puff volume predicted CO boost, and results suggest that smokers adjust their smoking behavior by cigarette blocking status. Those smokers who block filter vents may be increasing their exposure by 30%.
畅销淡味卷烟的过滤嘴通风口堵塞会增加标准机器测试中的烟雾产量，但不会增加吸烟者的临床研究。本研究的目的是调查(a)操纵卷烟过滤嘴通风口堵塞和(b)当天第一支烟的堵塞状态对一氧化碳(CO)提升的影响。参与者(n=25;万宝路淡薄荷烟吸烟者，年龄在 21-60 岁之间，每天至少吸 15 支烟，每天吸烟至少 5 年)完成了基于实验室的、个体内、双盲、交叉设计的 2 次吸烟试验，1 次使用吸烟地形设备，1 次不使用。每次试验包括吸 4 支烟；2 支过滤嘴通风口堵塞，2 支过滤嘴通风口不堵塞。两次试验之间收集的第一支日常香烟的过滤嘴进行评分，以确定过滤嘴通风口堵塞的情况。吸烟过滤嘴通风口堵塞的香烟显著增加了两次实验室试验中的 CO 提升(p<.001)。那些在当天第一支烟时堵塞过滤嘴的人(p=0.04)，在吸烟堵塞的香烟时，与吸烟未堵塞的香烟相比，CO 提升明显更大，与非堵塞者相比也是如此。当吸烟未堵塞和堵塞的香烟时，总吸气流速是 CO 提升的一个显著预测因素(p<.04)。与不堵塞过滤嘴通风口时相比，堵塞过滤嘴通风口显著增加了烟雾暴露，尤其是对于那些在当天第一支烟时堵塞过滤嘴通风口的人。总吸气流速预测 CO 提升，结果表明吸烟者通过香烟堵塞状态调整了吸烟行为。那些堵塞过滤嘴通风口的吸烟者可能会将其暴露量增加 30%。
