Fukuoka H, Goto A, Sasaki S
Hinyokika Kiyo. 1985 Sep;31(9):1667-74.
The clinical effectiveness of a new synthetic pyridoncarboxylic acid derivative, norfloxacin (NFLX: Baccidal) was studied in the urological field. NFLX was given clinically to 50 patients with urogenital tract infections; 40 cases were acute simple cystitis and 10 cases were complicated UTI satisfied the criteria of the UTI committee. Thirty two bacterial strains were isolated from the group of acute simple cystitis and 10 bacterial strains were isolated from the group of complicated UTI. Susceptibility of NFLX by the method of distribution and disk sensitivity was 97% in the former group and 89% in the latter group. The overall clinical efficacy rate estimated by the criteria of the UTI committee in 32 cases with acute simple cystitis was 97% and in 10 cases with complicated UTI was 60%. The incidence of side effect was 8.0% (4/50). All of these side effects which were nausea, abdominal fullness and headache may be attributable to the administration of NFLX. No abnormal laboratory findings were observed except for elevation in GOT and GPT values in 1 case (4.0%), which returned to normal after NFLX treatment. Therefore NFLX is suggested to be a clinically useful and safe drug in the treatment of UTI.
在泌尿领域对一种新型合成吡啶羧酸衍生物诺氟沙星（NFLX：拜克西达尔）的临床疗效进行了研究。临床上对50例泌尿生殖道感染患者使用了NFLX；其中40例为急性单纯性膀胱炎，10例复杂性泌尿道感染符合泌尿道感染委员会的标准。从急性单纯性膀胱炎组分离出32株细菌，从复杂性泌尿道感染组分离出10株细菌。采用分布法和纸片药敏法检测，NFLX对前一组的敏感性为97%，对后一组为89%。根据泌尿道感染委员会的标准评估，32例急性单纯性膀胱炎患者的总体临床有效率为97%，10例复杂性泌尿道感染患者为60%。副作用发生率为8.0%（4/50）。所有这些副作用，即恶心、腹胀和头痛，可能都归因于NFLX的给药。除1例（4.0%）谷草转氨酶和谷丙转氨酶值升高外，未观察到异常实验室检查结果，NFLX治疗后恢复正常。因此，NFLX被认为是治疗泌尿道感染的一种临床有用且安全的药物。
