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一种用于改善X线图像上内生软骨瘤检测的综合深度学习方法。

A comprehensive deep learning approach to improve enchondroma detection on X-ray images.

作者信息

Aydin Ayhan, Ozcan Caner, Simsek Safak Aydın, Say Ferhat

机构信息

Faculty of Engineering, Ondokuz Mayis University, 55200, Atakum, Samsun, Turkey.

Faculty of Engineering, Karabuk University, 78050, Kılavuzlar, Karabuk, Turkey.

出版信息

Sci Rep. 2025 Aug 20;15(1):30619. doi: 10.1038/s41598-025-07978-4.

Abstract

An enchondroma is a benign neoplasm of mature hyaline cartilage that proliferates from the medullary cavity toward the cortical bone. This results in the formation of a significant endogenous mass within the medullary cavity. Although enchondromas are predominantly asymptomatic, they may exhibit various clinical manifestations contingent on the size of the lesion, its localization, and the characteristics observed on radiological imaging. This study aimed to identify and present cases of bone tissue enchondromas to field specialists as preliminary data. In this study, authentic X-ray radiographs of patients were obtained following ethical approval and subjected to preprocessing. The images were then annotated by orthopedic oncology specialists using advanced, state-of-the-art object detection algorithms trained with diverse architectural frameworks. All processes, from preprocessing to identifying pathological regions using object detection systems, underwent rigorous cross-validation and oversight by the research team. After performing various operations and procedural steps, including modifying deep learning architectures and optimizing hyperparameters, enchondroma formation in bone tissue was successfully identified. This achieved an average precision of 0.97 and an accuracy rate of 0.98, corroborated by medical professionals. A comprehensive study incorporating 1055 authentic patient data from multiple healthcare centers will be a pioneering investigation that introduces innovative approaches for delivering preliminary insights to specialists concerning bone radiography.

摘要

内生软骨瘤是一种成熟透明软骨的良性肿瘤,从骨髓腔向皮质骨增殖。这导致在骨髓腔内形成一个显著的内生性肿块。尽管内生软骨瘤大多无症状,但它们可能会根据病变大小、位置以及放射影像学观察到的特征表现出各种临床表现。本研究旨在识别并向领域专家展示骨组织内生软骨瘤病例作为初步数据。在本研究中,经伦理批准后获取了患者的真实X线片并进行预处理。然后,骨科肿瘤专家使用经过多种架构框架训练的先进、最前沿的目标检测算法对图像进行标注。从预处理到使用目标检测系统识别病理区域的所有过程,均经过研究团队严格的交叉验证和监督。在执行了各种操作和程序步骤,包括修改深度学习架构和优化超参数后,成功识别出骨组织中的内生软骨瘤形成。这一结果经医学专业人员证实,平均精度达到0.97,准确率为0.98。一项纳入来自多个医疗中心的1055例真实患者数据的综合研究将是一项开创性调查,它将引入创新方法,为专家提供有关骨放射成像的初步见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f690/12368237/4a60c480728a/41598_2025_7978_Fig1_HTML.jpg

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