Lawrence K, Muggleton P W, Needham J R
Res Vet Sci. 1984 Jan;36(1):16-20.
Ceftazidime, a broad spectrum cephalosporin antibiotic with an enhanced anti-pseudomonal activity, was tested in vitro against a variety of reptilian bacterial isolates. Blood concentrations of this antibiotic were determined in clinically ill snakes following an intramuscular injection at a dose rate of 20 mg kg-1. Peak plasma levels of up to 70.5 micrograms ml-1 were reached one to eight hours after the injection and therapeutic plasma levels were maintained for at least 96 hours. A series of snakes treated with ceftazidime at a dose rate of 20 mg kg-1 every 72 hours showed a rapid and obvious clinical response to treatment. The snakes were maintained at 30 degrees C during treatment and the effect of environmental temperature on antibiotic half-life is discussed. Ceftazidime proved to be a highly active antibiotic against the bacteria known to cause disease in reptiles, with no obvious adverse effects having been so far described.
头孢他啶是一种具有增强抗假单胞菌活性的广谱头孢菌素抗生素，对多种爬行动物细菌分离株进行了体外测试。以20mg/kg的剂量率对临床患病的蛇进行肌肉注射后，测定了这种抗生素的血液浓度。注射后1至8小时达到高达70.5μg/ml的血浆峰值水平，治疗性血浆水平维持至少96小时。一系列以20mg/kg的剂量率每72小时用头孢他啶治疗的蛇对治疗表现出快速而明显的临床反应。治疗期间蛇饲养在30摄氏度，并讨论了环境温度对抗生素半衰期的影响。头孢他啶被证明是一种对已知可导致爬行动物疾病的细菌具有高活性的抗生素，目前尚未描述有明显的不良反应。
