Clark C H, Thomas J E, Milton J L, Goolsby W D
Am J Vet Res. 1982 Jul;43(7):1249-53.
The plasma concentrations of chloramphenicol after oral, IM, and IV administrations were studied in 15 species of birds. The biological half-lives of chloramphenicol ranged from 26 minutes in the pigeon, Columbia livia, to 288.3 minutes in the bald eagle, Haliaeetus leucocephalus. In those birds studied, the oral route gave low and inconsistent plasma chloramphenicol concentrations. The IM route was the most satisfactory. Based on the data presented, an IM dose of 50 mg/kg would produce plasma concentrations above 1 micrograms/ml for 8 to 12 hours, except in the pigeon, macaw, conure.
在15种鸟类中研究了口服、肌肉注射和静脉注射氯霉素后的血浆浓度。氯霉素的生物半衰期从家鸽（Columbia livia）的26分钟到白头海雕（Haliaeetus leucocephalus）的288.3分钟不等。在所研究的这些鸟类中，口服途径产生的血浆氯霉素浓度较低且不稳定。肌肉注射途径是最理想的。根据所提供的数据，50mg/kg的肌肉注射剂量将使血浆浓度在8至12小时内保持在1微克/毫升以上，但家鸽、金刚鹦鹉和锥尾鹦鹉除外。
