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具有分级结构和时空活性释放功能的花粉集成水凝胶贴片用于伤口愈合

Pollen Integrated Hydrogel Patches With Hierarchical Structures and Spatio-Temporal Actives Release for Wound Healing.

作者信息

Zhu Xinyu, Cai Lijun, Wang Yu, Chen Hong, Yu Chenjie, Zhao Yuanjin

机构信息

Department of Otolaryngology Head and Neck Surgery Nanjing Drum Tower Hospital Clinical Medical College of Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine Nanjing China.

School of Biological Science and Medical Engineering Southeast University Nanjing China.

出版信息

Smart Med. 2025 Aug 17;4(3):e70017. doi: 10.1002/smmd.70017. eCollection 2025 Sep.

DOI:10.1002/smmd.70017
PMID:40837201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12362785/
Abstract

Hydrogel patches have been serving as powerful tools for wound healing. Scientific attention in this field is focused on imparting the patches with novel structures, functions, and actives for promoting wound healing. In this paper, we have developed an innovative hydrogel patch with hierarchical structure and spatiotemporal actives release for efficient wound healing. This hydrogel patch was achieved by integrating asiatic acid (AA)-loaded pollens with chlorogenic acid (CA)-containing gelatin methacryloyl (GelMA) hydrogel. The high specific surface area and nanoporous structure of the pollens-integrated GelMA promote efficient loading and release of CA and AA, respectively. In wound treatment, the outer layer of GelMA first releases CA to fight infection. With the gradual degradation of GelMA, the pollens are exposed to the wounds and released AA, intensifying anti-inflammatory effects and promoting wound healing. These features indicate that this pollen-integrated hydrogel patch significantly accelerates the wound healing process in a spatiotemporal responsive manner, demonstrating great potential for clinical applications.

摘要

水凝胶贴片一直是伤口愈合的有力工具。该领域的科学关注重点在于赋予贴片新颖的结构、功能和活性成分以促进伤口愈合。在本文中，我们开发了一种具有分级结构和时空活性成分释放功能的创新水凝胶贴片，用于高效伤口愈合。这种水凝胶贴片是通过将负载积雪草苷（AA）的花粉与含绿原酸（CA）的甲基丙烯酰化明胶（GelMA）水凝胶整合而成。整合了花粉的GelMA的高比表面积和纳米多孔结构分别促进了CA和AA的高效负载和释放。在伤口治疗中，GelMA外层首先释放CA以对抗感染。随着GelMA的逐渐降解，花粉暴露于伤口并释放AA，增强抗炎作用并促进伤口愈合。这些特性表明，这种整合了花粉的水凝胶贴片以时空响应方式显著加速了伤口愈合过程，展现出巨大的临床应用潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c0/12362785/a516affaf042/SMMD-4-e70017-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c0/12362785/21ab08724528/SMMD-4-e70017-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c0/12362785/56b5096bba6f/SMMD-4-e70017-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c0/12362785/e1a15b991064/SMMD-4-e70017-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c0/12362785/1a24711764d3/SMMD-4-e70017-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c0/12362785/4d16e3101599/SMMD-4-e70017-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c0/12362785/a516affaf042/SMMD-4-e70017-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c0/12362785/21ab08724528/SMMD-4-e70017-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c0/12362785/56b5096bba6f/SMMD-4-e70017-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c0/12362785/e1a15b991064/SMMD-4-e70017-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c0/12362785/1a24711764d3/SMMD-4-e70017-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c0/12362785/4d16e3101599/SMMD-4-e70017-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c0/12362785/a516affaf042/SMMD-4-e70017-g007.jpg

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本文引用的文献

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Wound management materials and technologies from bench to bedside and beyond.从实验室到临床乃至更广泛应用的伤口管理材料与技术
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Emerging antibacterial nanozymes for wound healing.
用于伤口愈合的新型抗菌纳米酶
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Dynamic regulation of tissue fluidity controls skin repair during wound healing.动态调节组织流动性控制皮肤修复在伤口愈合过程中。
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