Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Negative Carbon Technologies, Suzhou Key Laboratory of Soft Material and New Energy, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
Adv Mater. 2024 Apr;36(15):e2307585. doi: 10.1002/adma.202307585. Epub 2024 Feb 8.
Hypoxia and infection are urgent clinical problems in chronic diabetic wounds. Herein, living Chlorella-loaded poly(ionic liquid)-based microneedles (PILMN-Chl) are constructed for microacupuncture oxygen and antibacterial therapy against methicillin-resistant Staphylococcus aureus (MRSA)-infected chronic diabetic wounds. The PILMN-Chl can stably and continuously produce oxygen for more than 30 h due to the photosynthesis of the loaded self-supported Chlorella. By combining the barrier penetration capabilities of microneedles, the continuous and sufficient oxygen supply of Chlorella, and the sterilization activities of PIL, the PILMN-Chl can accelerate chronic diabetic wounds in vivo by topical targeted sterilization and hypoxia relief in deep parts of wounds. Thus, the self-oxygen produced microneedles modality may provide a promising and facile therapeutic strategy for treating chronic, hypoxic, and infected diabetic wounds.
缺氧和感染是慢性糖尿病创面的紧急临床问题。在此，构建了负载活小球藻的聚离子液体基微针（PILMN-Chl），用于微针刺氧和抗耐甲氧西林金黄色葡萄球菌（MRSA）感染的慢性糖尿病创面的抗菌治疗。由于负载的自支撑小球藻的光合作用，PILMN-Chl 可以稳定且持续地产生氧气超过 30 h。通过结合微针的屏障穿透能力、小球藻的连续和充足的氧气供应以及 PIL 的杀菌活性，PILMN-Chl 可以通过局部靶向杀菌和缓解伤口深部的缺氧来加速体内慢性糖尿病伤口的愈合。因此，自供氧微针方式为治疗慢性、缺氧和感染性糖尿病创面提供了一种有前途的、简单的治疗策略。
