Truby Lauren K, Teuteberg Jeffrey
Assistant Professor of Medicine, Associate Medical Director, Adult Heart Transplant Program, Advanced Heart Failure and Transplantation, Department of Medicine, Division of Cardiology, UT Southwestern Medical Center, 5959 Harry Hines Boulevard, Dallas, TX 75390.
Associate Chief of Cardiology, Section Chief of Heart Failure, Cardiac Transplant and Mechanical Circulatory Support, Professor of Medicine, Division of Cardiology, CV 285, Falk Building, 300 Pasteur Drive, Stanford, CA 94305.
JHLT Open. 2025 Jul 25;10:100354. doi: 10.1016/j.jhlto.2025.100354. eCollection 2025 Nov.
Heart transplantation (HT) remains the optimal long-term therapy to improve survival in eligible patients living with end-stage heart disease. Monitoring the health of the allograft over its lifespan is critical to ensure the rapid diagnosis of immunologic, vascular, and myocardial events to enable the timely deployment of appropriate medical therapies. Advances in next-generation sequencing are being applied to screening for allograft rejection to the early detection of malignancy and have already been integrated into the routine care of HT recipients. Further personalization of care by integrating omics and imaging technologies, combined with novel data analysis methods, is at hand.
心脏移植（HT）仍然是改善终末期心脏病患者生存的最佳长期治疗方法。在同种异体移植物的整个生命周期内监测其健康状况对于确保快速诊断免疫、血管和心肌事件至关重要，以便能够及时部署适当的药物治疗。下一代测序技术的进展正被应用于同种异体移植物排斥反应的筛查以及恶性肿瘤的早期检测，并且已经被纳入心脏移植受者的常规护理中。通过整合组学和成像技术以及新颖的数据分析方法来进一步实现个性化护理已近在咫尺。
