Wang Lulu, Liu Yu, Ma Mengyao, Zhao Yifan, Bao Xiuli
Department of Ophthalmology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
School of Public Health, Inner Mongolia Medical University, Hohhot, China.
Front Med (Lausanne). 2025 Aug 5;12:1620042. doi: 10.3389/fmed.2025.1620042. eCollection 2025.
To investigate changes in subfoveal choroidal thickness (SFChT) and choriocapillaris (CC) perfusion in children wearing orthokeratology (Ortho-K) lenses.
This retrospective study included 61 myopic children, who were divided into two groups. The Ortho-K group wore Ortho-K lenses, while the control group wore single-vision distance spectacles. The SFChT, CC area and ocular parameters were measured before and after 1 week, 1 month, 3 months, and 6 months of treatment.
In the Ortho-K group, the SFChT significantly increased by 18.23 ± 11.35 μm. The CC area significantly increased by 0.39 ± 0.11 mm from baseline at the 1-week visit and continued to increase at the 1-month, 3-month, and 6-month follow-ups. In the control group, the choroidal parameters did not change significantly at 1 week. At the 1-, 3-, and 6-month follow-ups, the control group showed a notable reduction in SFChT and CC areas ( < 0.001). At the 6-month follow-up, there was a significant relationship between changes in SFChT and CC areas in the Ortho-K group ( = 0.890, < 0.001). The increasing SFChT and CC areas were negatively correlated with AL ( = -0.827, < 0.001; = -0.717, < 0.001), weakly negatively correlated with changes in VCD ( = -0.033, < 0.05; = -0.039, < 0.05), and negatively correlated with K1 and K2 ( = -0.430, < 0.001 and = -0.545, < 0.001, respectively; = -0.417, < 0.001 and = -0.464, < 0.001, respectively).
Orthokeratology notably increases SFChT and improves CC perfusion. Changes in choroidal thickness are linked to alterations in choriocapillaris perfusion. These effects are associated with the effect of orthokeratology in slowing axial length elongation.
研究佩戴角膜塑形镜（Ortho-K）的儿童黄斑中心凹下脉络膜厚度（SFChT）和脉络膜毛细血管（CC）灌注的变化。
这项回顾性研究纳入了61名近视儿童，分为两组。角膜塑形镜组佩戴角膜塑形镜，而对照组佩戴单焦点远视眼镜。在治疗1周、1个月、3个月和6个月前后测量SFChT、CC面积和眼部参数。
在角膜塑形镜组中，SFChT显著增加了18.23±11.35μm。CC面积在第1周随访时较基线显著增加了0.39±0.11mm，并在第1个月、3个月和6个月随访时持续增加。在对照组中，脉络膜参数在1周时无显著变化。在第1、3和6个月随访时，对照组的SFChT和CC面积显著减少（<0.001）。在第6个月随访时，角膜塑形镜组的SFChT和CC面积变化之间存在显著相关性（=0.890，<0.001）。SFChT和CC面积的增加与眼轴长度（AL）呈负相关（= -0.827，<0.001；= -0.717，<0.001），与玻璃体腔深度（VCD）变化呈弱负相关（= -0.033，<0.05；= -0.039，<0.05），与K1和K2呈负相关（分别为= -0.430，<0.001和= -0.545，<0.001；分别为= -0.417，<0.001和= -0.464，<0.001）。
角膜塑形术显著增加SFChT并改善CC灌注。脉络膜厚度的变化与脉络膜毛细血管灌注的改变有关。这些效应与角膜塑形术减缓眼轴长度伸长的作用相关。
