Li Zhouyue, Cui Dongmei, Hu Yin, Ao Sichun, Zeng Junwen, Yang Xiao
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Cont Lens Anterior Eye. 2017 Dec;40(6):417-423. doi: 10.1016/j.clae.2017.09.010. Epub 2017 Sep 19.
To analyze the change in subfoveal choroidal thickness (SFChT) and its relationship with changes in axial length (AL) in myopic children treated with Orthokeratology (Ortho-k).
Fifty myopic children participated in this study: 29 subjects were treated with Ortho-k lenses and 21 with single vision distance spectacles. The SFChT and ocular biometrics, including AL, were measured at baseline, one month, and six months after lens wear in both groups.
AL significantly increased in both groups over time. In the Ortho-k group, SFChT also increased; however, there was no significant change in SFChT in the control group over time. At the six-month visit, the magnitude of eye growth was significantly reduced in the Ortho-k group compared to the control group (0.06±0.10mm vs. 0.17±0.10mm, P<0.001). SFChT was significantly thicker in the Ortho-k group compared to the control group at the one-month and six-month visits (15.78±11.37μm vs. -2.98±8.96μm, P<0.001 (one-month visit); 21.03±12.74μm vs. -2.50±14.43μm, P<0.001 (six-month visit)), although there was no significant difference between the two follow-up visits (P=0.102 for the Ortho-k group; P=0.898 for the control group). Changes in the large choroidal vascular layer (LCVL) accounted for the majority of subfoveal choroidal thickening (approximately 77% and 80% at one-month and six-month visits, respectively).
Ortho-k treatment induced significant choroidal thickening and a slowing of eye growth. LCVL thickening accounted for the majority of SFChT thickening. However, its potential mechanism in myopia control requires further investigation.
分析接受角膜塑形术（Ortho-k）治疗的近视儿童的黄斑中心凹下脉络膜厚度（SFChT）变化及其与眼轴长度（AL）变化的关系。
50名近视儿童参与了本研究：29名受试者接受角膜塑形镜治疗，21名佩戴单光远用眼镜。两组均在戴镜前、戴镜1个月和6个月时测量SFChT及包括AL在内的眼部生物参数。
两组的AL均随时间显著增加。在角膜塑形镜组中，SFChT也增加；然而，对照组的SFChT随时间无显著变化。在6个月随访时，与对照组相比，角膜塑形镜组的眼轴增长幅度显著降低（0.06±0.10mm对0.17±0.10mm，P<0.001）。在1个月和6个月随访时，角膜塑形镜组的SFChT显著厚于对照组（15.78±11.37μm对-2.98±8.96μm，P<0.001（1个月随访）；21.03±12.74μm对-2.50±14.43μm，P<0.001（6个月随访）），尽管两次随访之间无显著差异（角膜塑形镜组P=0.102；对照组P=0.898）。脉络膜大血管层（LCVL）的变化占黄斑中心凹下脉络膜增厚的大部分（分别在1个月和6个月随访时约占77%和80%）。
角膜塑形术治疗可导致脉络膜显著增厚并减缓眼轴生长。LCVL增厚占SFChT增厚的大部分。然而，其在近视控制中的潜在机制需要进一步研究。
