Shao Minghai, Jiang Caiping, Yao Yunxiang, Yang Weifang, Jia Haijian, Shen Yichao, Wang Yanli, Yu Bin
Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Department of Radiation Oncology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China.
Afr Health Sci. 2025 Jun;25(2):153-160. doi: 10.4314/ahs.v25i2.20.
To explore the clinical effect compare between the simultaneous-integrated boost and sequential-boost intensity modulated radiotherapy in early breast cancer patients after breast conserving surgery.
According to the different postoperative radiotherapy methods, 66 early breast cancer patients after breast-conserving surgery were divided into two groups, 34 in the simultaneous-integrated boost group and 32 in the sequential-boost intensity group. Adverse reactions, cosmetic effects, local recurrence rate, progression-free survival and overall survival rates were compared.
No statistical significance in the incidence of acute skin reaction, advanced skin reaction, myelosuppression, radiation pneumonia and other adverse reactions between two groups were observed. The fine rate of simultaneous-integrated boost group was slightly better than the sequential-boost intensity group. And the follow-up rate of the two groups was 100%. The progression-free survival rate of the simultaneous-integrated boost group and the sequential-boost intensity group were 100% and 96.88%, respectively; The overall survival rates of the two groups were all 100%; One patient in the sequential-boost intensity group had recurrence (3.13%), while none in the simultaneous-integrated boost group. No significant difference in local recurrence rate, progression-free survival and overall survival rates in the two groups were found.
Simultaneous-integrated boost ensures breast appearance and survival without added radiotherapy side effects vs sequential-boost intensity.
探讨保乳手术后早期乳腺癌患者同步整合加量调强放疗与序贯加量调强放疗的临床效果比较。
根据术后不同放疗方法，将66例保乳手术后的早期乳腺癌患者分为两组，同步整合加量组34例，序贯加量组32例。比较两组不良反应、美容效果、局部复发率、无进展生存率和总生存率。
两组急性皮肤反应、晚期皮肤反应、骨髓抑制、放射性肺炎等不良反应发生率无统计学差异。同步整合加量组的优良率略优于序贯加量组。两组随访率均为100%。同步整合加量组和序贯加量组的无进展生存率分别为100%和96.88%；两组总生存率均为100%；序贯加量组1例患者复发（3.13%），同步整合加量组无复发。两组局部复发率、无进展生存率和总生存率无显著差异。
与序贯加量相比，同步整合加量在不增加放疗副作用的情况下可确保乳房外观和生存率。
