Cui Manxiu, Kahraman S Süleyman, Wang Lihong V
Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
Nat Commun. 2025 Aug 21;16(1):7807. doi: 10.1038/s41467-025-63095-w.
Guide star-assisted time-reversal enables deep optical focusing in scattering media such as biological tissue, overcoming the diffusion limit of light. However, in practice, guide stars formed using contrast agents or ultrasonic modulation naturally occupy regions much larger than the optical resolution, thus limiting their effectiveness. We propose and experimentally demonstrate a time-reversal focusing mechanism in scattering media that achieves focusing to a single speckle grain without the need for point-like guide stars. We exploit optical absorption nonlinearity as a light-induced perturbation to create virtual guide stars. The back-scattered fields in response to high- and low-intensity illuminations are subtracted after scaling to synthesize the field from the dominant speckle grains in the medium. We use this time-reversed field as the incident illumination in subsequent iterations. The focusing is achieved despite the extended layer of nonlinear absorber via a positive feedback loop that favors higher-intensity speckle grains, converging to a single virtual guide star at the optical resolution. We also demonstrate that by adding a phase ramp in each iteration, this focus can be gradually steered beyond the memory effect range.
导星辅助的时间反演能够在诸如生物组织等散射介质中实现深度光学聚焦,克服了光的扩散极限。然而,在实际应用中,使用造影剂或超声调制形成的导星自然占据的区域比光学分辨率大得多,从而限制了它们的有效性。我们提出并通过实验证明了一种散射介质中的时间反演聚焦机制,该机制无需点状导星即可实现聚焦到单个散斑颗粒。我们利用光吸收非线性作为光致微扰来创建虚拟导星。在缩放后,将对高强度和低强度照明的反向散射场相减,以合成来自介质中主要散斑颗粒的场。我们将这个时间反演场用作后续迭代中的入射照明。尽管存在非线性吸收体的扩展层,但通过有利于更高强度散斑颗粒的正反馈回路,在光学分辨率下收敛到单个虚拟导星,从而实现聚焦。我们还证明,通过在每次迭代中添加相位斜坡,可以将这个焦点逐渐引导到超出记忆效应范围。