胆红素会增加线粒体内膜的通透性。
Bilirubin increases mitochondrial inner membrane conductance.
作者信息
Stumpf D A, Eguren L A, Parks J K
出版信息
Biochem Med. 1985 Oct;34(2):226-9. doi: 10.1016/0006-2944(85)90115-2.
PMID:4084246
Abstract
Bilirubin accumulates within, and induces loose coupling in, rat liver mitochondria. This state, characterized by a normal protonmotive force, but increased oxygen consumption and inner membrane conductance, could impair cellular energy metabolism. Loose coupling is observed at bilirubin concentrations (12-24 microM) attained in tissues of kernicteric animals.
摘要
胆红素在大鼠肝脏线粒体中蓄积，并诱导其发生解偶联。这种状态的特征是质子动力正常，但氧消耗增加且内膜电导增加，可能会损害细胞能量代谢。在核黄疸动物组织中达到的胆红素浓度（12 - 24微摩尔）下可观察到解偶联现象。
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