Huang Shaoyang, Li Jiangyan, Gu Dandan, Li Zhengliang, Chen Hongyun, Xiong Wei
College of Basic Medical Sciences, Dali University, Dali, China.
College of Life Sciences, Shaanxi Normal University, Xi'an, China.
Front Microbiol. 2025 Aug 6;16:1623875. doi: 10.3389/fmicb.2025.1623875. eCollection 2025.
BACKGROUND: The human body's intestinal microbiota is a vital "organ" that coexists with it and is intimately linked to both human health and illness. Human intestinal microbiota and its metabolites are a crucial component in the development of several diseases, according to an increasing number of studies that have started to examine the function of intestinal microbiota in various illnesses. Numerous recent studies have also shown a direct relationship between cellular senescence and the gut flora. The purpose of this study was to use bibliometric techniques to examine the themes and subjects of scholarly publications in this discipline during the past 10 or so years. METHOD: The Web of Science Core Collection (WOSCC) database was searched for material published between 2015 and 2025. The study used VOSviewer and Citespace to explore the characteristics of this literature. Specific analyzes covered the number of publications, countries/regions studied, research institutions, authors, journals, citations, and keyword hotspots. RESULTS: This study analyzed 2,911 publications on research related to gut microbiota and cellular senescence between 2015 and 2025, with a rapid increase in annual publications from 2020 onwards, peaking in 2024 (492 publications), with the United States and China dominating in terms of publications, and the University of Groningen demonstrating excellent academic influence in this field, with Chen, Wei, De Vos, Paul and Zhang, Hao being the three most influential authors in this field, Nature is the most influential journal in its field with 5,857 total citations, "Oxidative stress," "Alzheimer's disease" and "immunotherapy" are current hot topics of research. CONCLUSION: Research in the field of gut microbiota and cellular aging is growing rapidly. Current research focuses on gut microbiota and disease mechanisms (e.g., Alzheimer's disease, immunotherapy, oxidative stress) and clinical translation, and interdisciplinary collaborations and technological innovations are expected to drive further development in this field. This bibliometric study provides a comprehensive analysis of the field and offers new ideas for future research.
背景：人体肠道微生物群是与其共存的重要“器官”，与人类健康和疾病密切相关。越来越多的研究开始探讨肠道微生物群在各种疾病中的作用，这些研究表明，人类肠道微生物群及其代谢产物是多种疾病发生发展的关键因素。最近的许多研究还表明细胞衰老与肠道菌群之间存在直接关系。本研究的目的是运用文献计量学技术，考察过去10年左右该学科领域学术出版物的主题和课题。 方法：在科学网核心合集（WOSCC）数据库中检索2015年至2025年发表的资料。本研究使用VOSviewer和Citespace来探究该文献的特征。具体分析内容包括出版物数量、研究的国家/地区、研究机构、作者、期刊、被引频次以及关键词热点。 结果：本研究分析了2015年至2025年间2911篇关于肠道微生物群与细胞衰老相关研究的出版物，自2020年起年出版物数量迅速增加，在2024年达到峰值（492篇出版物），出版物数量方面美国和中国占据主导地位，格罗宁根大学在该领域展现出卓越的学术影响力，陈、魏、德沃斯、保罗以及张浩是该领域最具影响力的三位作者，《自然》是其领域内最具影响力的期刊，总被引频次达5857次，“氧化应激”“阿尔茨海默病”和“免疫疗法”是当前的研究热点。 结论：肠道微生物群与细胞衰老领域的研究正在迅速发展。当前的研究集中在肠道微生物群与疾病机制（如阿尔茨海默病、免疫疗法、氧化应激）以及临床转化方面，跨学科合作和技术创新有望推动该领域的进一步发展。这项文献计量学研究对该领域进行了全面分析，并为未来研究提供了新思路。
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