Johansson T, Berrez J M, Nelson B D
Biochem Biophys Res Commun. 1985 Dec 17;133(2):608-13. doi: 10.1016/0006-291x(85)90948-9.
The level of hexokinase-specific mRNA in rat liver and in rat ascites hepatoma (Zajdela) was assessed by translating free polysomes from both cell types in a reticulocyte lysate. Translation of hexokinase occurred with approximately a 10 fold higher frequency in tumor cells than in liver, suggesting that transcriptional activation is in part responsible for increased levels of hexokinase in tumor.
通过在网织红细胞裂解物中翻译来自这两种细胞类型的游离多核糖体，评估了大鼠肝脏和大鼠腹水肝癌（扎伊德拉）中己糖激酶特异性mRNA的水平。己糖激酶在肿瘤细胞中的翻译频率比在肝脏中高约10倍，这表明转录激活在一定程度上导致了肿瘤中己糖激酶水平的升高。
