Stoyanov George S, Balabanov Ivaylo, Zhivkova Svetoslava, Popov Hristo
Department of Pathology, Multiprofile Hospital for Active Treatment, 9700 Shumen, Bulgaria.
Department of Obstetrics and Gynecology, Multiprofile Hospital for Active Treatment, 9700 Shumen, Bulgaria.
Reports (MDPI). 2025 Aug 1;8(3):130. doi: 10.3390/reports8030130.
Trichoblastomas are rare, mixed epithelial tumors with a mesenchymal component and hair follicle differentiation. Herein, we present a case report of a 51-year-old female patient presenting to the obstetrics and gynecology department with complaints of edema and erythema of the right Bartholin gland, and a lesion measuring 2 cm on the right lateral edge of the mons pubis, towards the inguinal fold. Marsupialization of the Bartholin gland was performed, as well as an incision into the pubo-inguinal lesion, which the patient depicted as grossly resembling an ingrown hair. Upon incision into the pubic-inguinal lesion, it was dark brown in color and spontaneously popped out of the subcutis, without an attempt at enucleation. Histology and subsequent immunohistochemistry of the lesion showed a blue basaloid tumor with an extensive pigment component located deep in the dermis that was sharply demarcated from the surrounding tissues. Immunohistochemistry was diffusely and strongly positive for epithelial markers; melanocytic markers were positive only in dendritic melanocytes dispersed within the tumors, and the proliferative index was low. As such, the tumor was identified as melanotrichoblastoma.
毛发母细胞瘤是一种罕见的、具有间充质成分和毛囊分化的混合性上皮肿瘤。在此，我们报告一例51岁女性患者，该患者因右巴氏腺水肿和红斑以及耻骨联合右侧边缘靠近腹股沟皱襞处有一个2厘米大小的肿物而就诊于妇产科。对巴氏腺进行了造袋术，并对耻骨-腹股沟肿物进行了切开，患者称该肿物外观极像内生毛发。切开耻骨-腹股沟肿物后，其呈深褐色，且自行从皮下突出，未尝试摘除。该肿物的组织学检查及后续免疫组化显示为一个蓝色基底样肿瘤，在真皮深层有广泛的色素成分，与周围组织界限清晰。免疫组化显示上皮标志物弥漫性强阳性；黑素细胞标志物仅在散在于肿瘤内的树突状黑素细胞中呈阳性，增殖指数较低。因此，该肿瘤被诊断为黑素毛发母细胞瘤。
