Latzman Robert D, Taglialatela Jared P, Hopkins William D
Department of Psychology, Georgia State University, Atlanta, GA, USA
Department of Biology and Physics, Kennesaw State University, Kennesaw, GA, USA Division of Developmental and Cognitive Neuroscience, Yerkes National Primate Research Center, Atlanta, GA, USA.
Proc Biol Sci. 2015 Jun 22;282(1809):20150764. doi: 10.1098/rspb.2015.0764.
Individual variability in delay of gratification (DG) is associated with a number of important outcomes in both non-human and human primates. Using diffusion tensor imaging (DTI), this study describes the relationship between probabilistic estimates of white matter tracts projecting from the caudate to the prefrontal cortex (PFC) and DG abilities in a sample of 49 captive chimpanzees (Pan troglodytes). After accounting for time between collection of DTI scans and DG measurement, age and sex, higher white matter connectivity between the caudate and right dorsal PFC was found to be significantly associated with the acquisition (i.e. training phase) but not the maintenance of DG abilities. No other associations were found to be significant. The integrity of white matter connectivity between regions of the striatum and the PFC appear to be associated with inhibitory control in chimpanzees, with perturbations on this circuit potentially leading to a variety of maladaptive outcomes. Additionally, results have potential translational implications for understanding the pathophysiology of a number of psychiatric and clinical outcomes in humans.
在非人类和人类灵长类动物中，延迟满足（DG）的个体差异与许多重要结果相关。本研究使用扩散张量成像（DTI），描述了49只圈养黑猩猩（Pan troglodytes）样本中从尾状核投射到前额叶皮层（PFC）的白质束概率估计与DG能力之间的关系。在考虑DTI扫描采集与DG测量之间的时间、年龄和性别后，发现尾状核与右侧背侧PFC之间较高的白质连通性与DG能力的获得（即训练阶段）显著相关，但与DG能力的维持无关。未发现其他关联具有显著性。纹状体区域与PFC之间白质连通性的完整性似乎与黑猩猩的抑制控制有关，该回路的扰动可能导致各种适应不良的结果。此外，研究结果对于理解人类多种精神和临床结果的病理生理学具有潜在的转化意义。
