刺激多巴胺2型受体可降低人眼内压。
Stimulation of dopamine receptors (type 2) lowers human intraocular pressure.
作者信息
Mekki Q A, Turner P
出版信息
Br J Ophthalmol. 1985 Dec;69(12):909-10. doi: 10.1136/bjo.69.12.909.
Abstract
The interaction between bromocriptine and metoclopramide on intraocular pressure (IOP), pupil diameter, and other parameters were studied in healthy volunteers. Pupil diameter was not affected by both treatments and only bromocriptine lowered IOP. Prior treatment with metoclopramide blocked the IOP-lowering effect of bromocriptine. It is concluded that bromocriptine lowers IOP by stimulation of dopamine-2 receptors.
摘要
在健康志愿者中研究了溴隐亭与甲氧氯普胺对眼压（IOP）、瞳孔直径及其他参数的相互作用。两种治疗均未影响瞳孔直径，只有溴隐亭降低了眼压。预先用甲氧氯普胺治疗可阻断溴隐亭的降眼压作用。得出的结论是，溴隐亭通过刺激多巴胺2受体降低眼压。
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本文引用的文献
1
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Br J Ophthalmol. 1981 Aug;65(8):536-8. doi: 10.1136/bjo.65.8.536.
2
Metoclopramide. An updated review of its pharmacological properties and clinical use.甲氧氯普胺。对其药理特性及临床应用的最新综述。
Drugs. 1983 May;25(5):451-94. doi: 10.2165/00003495-198325050-00002.
3
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4
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5
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Arch Int Pharmacodyn Ther. 1982 Nov;260(1):83-90.
6
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Am J Optom Arch Am Acad Optom. 1972 Aug;49(8):646-60. doi: 10.1097/00006324-197208000-00005.
7
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Life Sci. 1978 Aug 14;23(6):545-9. doi: 10.1016/0024-3205(78)90032-2.
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