溴隐亭对糖尿病自主神经病变患者眼压降低作用的初步研究。
A preliminary study of the ocular hypotensive effects of bromocriptine in diabetic patients with autonomic neuropathy.
作者信息
al-Sereiti M R, Turner P, Gale E A
机构信息
Department of Clinical Pharmacology, St Bartholomew's Hospital, London, UK.
出版信息
Postgrad Med J. 1991 Apr;67(786):347-9. doi: 10.1136/pgmj.67.786.347.
Abstract
The effect of bromocriptine on intraocular pressure has been investigated in a group of 8 diabetic patients with autonomic neuropathy, to test the hypothesis that bromocriptine exerts its ocular hypotensive action through presynaptic dopamine receptors. Bromocriptine eye drops (0.025%) produced a significant fall in intraocular pressure in a control group of 8 matched normal volunteers, but this effect was not seen in the eyes of the diabetic patients. These results are consistent with a presynaptic site of action of bromocriptine.
摘要
研究了溴隐亭对一组8例患有自主神经病变的糖尿病患者眼压的影响，以检验溴隐亭通过突触前多巴胺受体发挥其降眼压作用这一假说。在8名匹配的正常志愿者组成的对照组中，溴隐亭滴眼液（0.025%）可使眼压显著降低，但在糖尿病患者眼中未观察到这种效果。这些结果与溴隐亭的突触前作用位点一致。
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本文引用的文献
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Bromocriptine eyedrops lower intraocular pressure without affecting prolactin levels.溴隐亭滴眼液可降低眼压，且不影响催乳素水平。
Lancet. 1984 Feb 4;1(8371):287-8. doi: 10.1016/s0140-6736(84)90162-4.
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Bromocriptine lowers intraocular pressure without affecting blood pressure.溴隐亭可降低眼压而不影响血压。
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Stimulation of dopamine receptors (type 2) lowers human intraocular pressure.刺激多巴胺2型受体可降低人眼内压。
Br J Ophthalmol. 1985 Dec;69(12):909-10. doi: 10.1136/bjo.69.12.909.
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Bromocriptine, dopamine and glaucoma.溴隐亭、多巴胺与青光眼
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A simple diagnostic test for pupillary abnormality in diabetic autonomic neuropathy.一种用于诊断糖尿病性自主神经病变瞳孔异常的简易检测方法。
Diabet Med. 1986 Jan;3(1):38-41. doi: 10.1111/j.1464-5491.1986.tb00703.x.
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The effects of lisuride, terguride and bromocriptine on intraocular pressure (IOP).利苏瑞肽、特古瑞肽和溴隐亭对眼压（IOP）的影响。
Br J Clin Pharmacol. 1989 Feb;27(2):159-63. doi: 10.1111/j.1365-2125.1989.tb05346.x.
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