Barapatre Nirav, Frank David, von Koch Franz Edler, Grundmann Sven, Frank Hans-Georg, Bruschewski Martin
Department of Anatomy II, LMU Munich, Munich 80336, Germany.
MRI Flow Lab, University Rostock, Rostock 18059, Germany.
Sci Adv. 2025 Aug 22;11(34):eadw9753. doi: 10.1126/sciadv.adw9753.
Doppler measurements of the uterine arteries are indirect measures of the uteroplacental blood flow. Given that the intervillous flow cannot be resolved by clinical imaging, theoretical models are used to study the flow dynamics in the intervillous space (IVS). We propose an experimental method to visualize the flow within the IVS of a single placental cotyledon postpartum. At first, a cotyledon is measured by micro-computed tomography imaging. The reconstructed volume is then used to create a near-realistic placenta model. Four variations of arterial inlets are designed to simulate both normal and abnormal flow patterns. A scaled version of the model is printed in three dimensions. Magnetic resonance imaging-based velocity measurements inside the printed model, which is perfused with a Newtonian fluid at two Reynolds numbers, revealed that the flow patterns are primarily influenced by the Reynolds number and the dilation of the arterial inlet. The spiralization of the arterial pathway had only a minimal impact.
子宫动脉的多普勒测量是子宫胎盘血流的间接测量方法。鉴于临床成像无法分辨绒毛间隙血流，因此使用理论模型来研究绒毛间隙（IVS）中的流动动力学。我们提出了一种实验方法，用于在产后可视化单个胎盘小叶IVS内的血流。首先，通过微型计算机断层扫描成像测量一个小叶。然后，利用重建的体积创建一个近乎真实的胎盘模型。设计了四种动脉入口变体，以模拟正常和异常的血流模式。该模型的缩放版本以三维方式打印。在灌注了两种雷诺数的牛顿流体的打印模型内，基于磁共振成像的速度测量结果表明，血流模式主要受雷诺数和动脉入口扩张的影响。动脉路径的螺旋化影响极小。
