Mokhtari Mojgan, Kouhpayeh Hamidreza
Shahid AkbarAbadi Clinical Research Development Unit (SHACRDU), School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Infectious Disease and Tropical Medicine Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran.
Ann Med Surg (Lond). 2025 Apr 25;87(7):4384-4394. doi: 10.1097/MS9.0000000000003282. eCollection 2025 Jul.
Contradictory data exists regarding COVID-19's impact on pregnancy outcomes. This study will compare pandemic pregnancy outcomes to pre-pandemic levels in local, regional, and national populations.
We searched three international electronic databases (PubMed) for research on COVID-19 infection and pregnancy outcomes from the first accessible to 10 December 2021. We included articles on COVID-19's effects on pregnancy, maternal, and neonatal outcomes, using pregnancy as the main endpoint.
Twenty-eight studies were examined. The exposed population sampled 1 476 827, and the total sample was 23 819 822. One-third of studies found a pandemic-related increase in maternal mortality. Six of fourteen stillbirth studies showed a substantial increase. Ten of fourteen studies found no substantial increase in preterm birth rates. After the pandemic, postnatal depression, maternal anxiety, or both increased in five of nine mother mental health studies.
There is a significant increase in postnatal maternal mental disorders and a probable increase in maternal mortality and stillbirth compared to before the pandemic. However, our study's findings might result from healthcare inefficiency. COVID-19 vaccination is highly recommended for pregnant and breastfeeding women.
关于新冠病毒病（COVID-19）对妊娠结局的影响，存在相互矛盾的数据。本研究将比较本地、区域和全国人群中疫情期间与疫情前的妊娠结局。
我们检索了三个国际电子数据库（PubMed），以查找2021年12月10日之前可获取的关于COVID-19感染与妊娠结局的研究。我们纳入了以妊娠为主要终点，关于COVID-19对妊娠、孕产妇和新生儿结局影响的文章。
共审查了28项研究。暴露人群样本为1476827例，总样本为23819822例。三分之一的研究发现疫情相关的孕产妇死亡率有所上升。14项死产研究中有6项显示大幅上升。14项研究中有10项发现早产率没有大幅上升。疫情之后，9项母亲心理健康研究中有5项显示产后抑郁、孕产妇焦虑或两者均有所增加。
与疫情前相比，产后孕产妇精神障碍显著增加，孕产妇死亡率和死产可能增加。然而，我们研究的结果可能是由于医疗保健效率低下所致。强烈建议孕妇和哺乳期妇女接种COVID-19疫苗。
