Antimicrobial resistance profiles of spp. and isolated from dogs and cats in Seoul, South Korea during 2021-2023.

We investigated the antimicrobial resistance (AMR) rates and profiles of spp. and () isolated from dogs and cats in Seoul, South Korea during 2021-2023. We analyzed AMR profiles of spp. and isolated from 2,180 samples (1,859 canine and 321 feline) collected from 36 veterinary clinics in Seoul, South Korea, as part of the Korean Veterinary Antimicrobial Resistance Monitoring System (2021-2023). A total of 484 spp. isolates and 158 isolates were identified and used for AMR test. spp. isolates exhibited the highest resistance to penicillin in both dogs (85%) and cats (29.81%). Multidrug-resistant (MDR) spp. was more prevalent in dogs (65%) than in cats (14.42%), with three isolates from dogs and a isolate from a cat showing resistance to eight antibiotic classes. Methicillin-resistant (MRSP) constituted 105 out of 284 isolates (36.97%) in dogs and seven strains out of 14 (50%) in cats. isolates demonstrated the highest resistance to cefalexin in both dogs (61.72%) and cats (56.67%). The prevalence of MDR was higher in dogs (37.5%) than in cats (26.67%). This study highlights the concerning prevalence of AMR in commensal or potentially opportunistic pathogens from companion animals, particularly in dogs. It is crucial to promote the prudent use of antimicrobials in companion animals and ensure the ongoing monitoring of trends in antimicrobial-resistant bacteria to mitigate the selection and spread of antibiotic-resistant bacteria between humans and companion animals.