Jiang Yan-Qiu, Gao Ang, Fu Ming-Chen
Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology Hefei 230009 China
Chem Sci. 2025 Aug 12. doi: 10.1039/d5sc05002b.
We herein report a catalyst- and thiol-free method for synthesizing thioesters from arenes, carboxylic acids, and tetramethylthiourea in a one-pot process, by combining arene activation the interrupted Pummerer reaction with an electron donor-acceptor complex strategy. The method enables late-stage modification of complex bioactive molecules, and operates effectively under natural sunlight, highlighting its potential synthetic value.
我们在此报告一种无催化剂和硫醇的方法，该方法通过将芳烃活化、中断的普默勒尔反应与电子供体-受体络合物策略相结合，在一锅法中由芳烃、羧酸和四甲基硫脲合成硫酯。该方法能够对复杂的生物活性分子进行后期修饰，并在自然阳光下有效运行，突出了其潜在的合成价值。
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