Autzen T, Larsen F E, Christensen N J
Curr Eye Res. 1985 Dec;4(12):1269-71. doi: 10.3109/02713688509017686.
Timolol of 0.5% was applied in 6 eyes prior to cataract extraction, while 7 eyes were not treated. Aqueous humor was drawn after retrobulbar analgesia with 2% lidocaine and analyzed for epinephrine and norepinephrine using a radioenzymatic assay. Epinephrine levels averaged 15.8 +/- 16.2 and 19.3 +/- 27.5 pg/ml in the timolol treated group and controls respectively. The corresponding values for norepinephrine were 1.59 +/- 0.55 and 1.87 +/- 0.90 ng/ml. These differences were not statistically significant. Norepinephrine levels in this study were somewhat higher than in previous reports of catecholamine levels in human aqueous humor and considerably higher than plasma levels of norepinephrine. There was no significant correlation between aqueous humor norepinephrine levels and age in the two groups combined. The mean norepinephrine levels for men and women in the two groups combined were 1.73 +/- 0.89 and 1.76 +/- 0.56 ng/ml. The difference was not statistically significant. Timolol resulted in a decrease in the intraocular pressure.
在白内障摘除术前，对6只眼应用了0.5%的噻吗洛尔，而7只眼未接受治疗。在球后注射2%利多卡因进行镇痛后抽取房水，并用放射酶分析法分析其中的肾上腺素和去甲肾上腺素。噻吗洛尔治疗组和对照组的肾上腺素水平分别平均为15.8±16.2和19.3±27.5 pg/ml。去甲肾上腺素的相应值分别为1.59±0.55和1.87±0.90 ng/ml。这些差异无统计学意义。本研究中的去甲肾上腺素水平略高于以往关于人房水中儿茶酚胺水平的报告，且显著高于血浆中的去甲肾上腺素水平。两组房水中去甲肾上腺素水平与年龄之间无显著相关性。两组合并后男性和女性的平均去甲肾上腺素水平分别为1.73±0.89和1.76±0.56 ng/ml。差异无统计学意义。噻吗洛尔可降低眼压。
