艾灸治疗化疗所致白细胞减少症的疗效比较：一项贝叶斯网络Meta分析。

Comparative efficacy of moxibustion in chemotherapy-induced leukopenia: A Bayesian network meta-analysis.

作者信息

Li Zun-Yuan, Chen Chun-Lan, Li Xiao-Yan, Huo Wen-Ge, Yang Yan, Guo Yu-Hong, Liu Zhi-Dan

机构信息

Department of Acupuncture, Baoshan Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Department of Acupuncture, Baoshan Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai, China.

出版信息

Integr Med Res. 2025 Jun;14(2):101145. doi: 10.1016/j.imr.2025.101145. Epub 2025 Apr 15.

DOI:10.1016/j.imr.2025.101145

PMID:40852638

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12368775/

Abstract

BACKGROUND

Moxibustion has been applied in various clinical treatments, including chemotherapy-induced leukopenia. Using a Bayesian network meta-analysis, this study assessed a wide range of published data to identify the most efficient and effective method of moxibustion therapy for treating chemotherapy-induced leukopenia.

METHODS

PubMed, EMBASE, and eight other databases plus two clinical trial registration platforms were searched from their respective inception date to January 2024. All randomized controlled trials (RCTs) of moxibustion for chemotherapy-induced leukopenia were included. The primary outcome indicator was white blood cell count, and the secondary outcome was the Karnofsky performance status score. Stata (version 17.0) and the gemtc package (version 1.0-0) of R (version 4.3.1) were used to perform the network meta-analysis.

RESULTS

Thirty RCTs with 2282 total patients involving 12 types of moxibustion-related therapies were identified. Results of the surface under the cumulative ranking curve revealed the following treatments as most effective for leukopenia: thunder-fire moxibustion combined with medication (95.9 %), grain-sized moxibustion combined with medication (76.2 %), and herb-separated moxibustion (76.0 %). Grain-sized moxibustion combined with medication (76.5 %) ranked first in improving Karnofsky performance status scores.

CONCLUSION

Thunder-fire moxibustion combined with medication appears to be the most effective treatment for chemotherapy-induced leukopenia.

PROTOCOL REGISTRATION

This study is registered in the International Prospective Register of Systematic Reviews (PROSPERO) database, registration number CRD42023402588.

摘要

背景

艾灸已应用于各种临床治疗，包括化疗引起的白细胞减少症。本研究采用贝叶斯网络荟萃分析，评估了大量已发表的数据，以确定治疗化疗引起的白细胞减少症最有效且高效的艾灸疗法。

方法

检索了PubMed、EMBASE和其他八个数据库以及两个临床试验注册平台，检索时间从各数据库创建之日至2024年1月。纳入了所有关于艾灸治疗化疗引起的白细胞减少症的随机对照试验（RCT）。主要结局指标为白细胞计数，次要结局为卡氏功能状态评分。使用Stata（17.0版）和R（4.3.1版）的gemtc包（1.0 - 0版）进行网络荟萃分析。