Harerimana Nadia V, Liu Yixuan, Ruks Mirko
Max Planck Research Group Biosocial - Biology, Social Disparities, and Development, Max Planck Institute for Human Development, Berlin, Germany.
Faculty of Sociology, Bielefeld University, Bielefeld, Germany.
PLoS One. 2025 Aug 25;20(8):e0316416. doi: 10.1371/journal.pone.0316416. eCollection 2025.
Both genetic influences and neighborhood environments play a role in shaping life satisfaction. However, research examining gene-environment interactions (GxE) in this context remains limited. This study investigates how neighborhood deprivation moderates the effects of genetic influences on life satisfaction. Using data from 760 dizygotic (DZ) twin pairs in the German Twin Family Panel (TwinLife), we apply twin fixed-effect models to estimate GxE effects. Results indicate that a Polygenic index (PGI) for subjective well-being is positively associated with life satisfaction. Notably, this association is strongest among individuals living in moderately deprived neighborhoods, and weaker in both highly deprived and less deprived areas. Thus, there are signs of compensation in less deprived areas and, particularly, diathesis-stress/triggering in highly deprived areas.
遗传影响和邻里环境在塑造生活满意度方面都发挥着作用。然而，在这种背景下研究基因-环境相互作用（GxE）的研究仍然有限。本研究调查了邻里贫困如何调节遗传影响对生活满意度的作用。利用德国双胞胎家庭面板（TwinLife）中760对异卵（DZ）双胞胎的数据，我们应用双胞胎固定效应模型来估计GxE效应。结果表明，主观幸福感的多基因指数（PGI）与生活满意度呈正相关。值得注意的是，这种关联在生活在中度贫困社区的个体中最为强烈，而在高度贫困和贫困程度较低的地区则较弱。因此，在贫困程度较低的地区有补偿迹象，特别是在高度贫困地区有素质-应激/触发迹象。
