静脉注射入小鼠体内的标记脂肪酸特性对心肌和血液活性过程的影响。
Influence on the myocardial and blood activity course of the characteristics of the labelled fatty acid injected i.v. into mice.
作者信息
Keriel C, Bontemps L, Demaison L, Mathieu J P, Marti-Batlle D, Pernin C, Riche F, Vidal M, Godart J, Cuchet P
出版信息
Eur Heart J. 1985 Aug;6 Suppl B:13-9. doi: 10.1093/eurheartj/6.suppl_b.13.
In order to choose a labelled fatty acid (FA) for the external study of myocardial metabolism, FAs that are different in chain length, saturation, nature and position of the radioactive label, are injected i.v. into mice. Myocardial and blood activities are measured at various times p.i. It appears that hexadecanoic and hexadecenoic acids, iodine labelled in omega position, have the highest maximal myocardial activity among all the FAs studied. Furthermore, the myocardial and blood time-activity course is similar for both FAs. As unsaturated FAs have apparently a higher myocardial fixation in man than the saturated ones, 123I 16 iodo-9 hexadecenoic acid has been selected and seems well suited for the study of myocardial metabolism.
为了选择一种用于心肌代谢体外研究的标记脂肪酸（FA），将链长、饱和度、放射性标记的性质和位置不同的脂肪酸静脉注射到小鼠体内。在注射后不同时间测量心肌和血液活性。结果显示，在所有研究的脂肪酸中，ω位碘标记的十六烷酸和十六碳烯酸具有最高的最大心肌活性。此外，这两种脂肪酸的心肌和血液时间-活性过程相似。由于不饱和脂肪酸在人体中的心肌摄取明显高于饱和脂肪酸，因此选择了123I 16-碘-9-十六碳烯酸，它似乎非常适合用于心肌代谢研究。
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