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[Synthesis and pharmacologic study of 6-(amino-2 ethyl) benzoxazolinones].

作者信息

Caignard D H, Couquelet J, Lesieur D, Lespagnol C, Lamar J C, Beaughard M, Leinot M, Tisne-Versailles J

出版信息

Farmaco Sci. 1985 Nov;40(11):854-68.

PMID:4085645
Abstract

Reaction of various amines on 6-(2-bromoethyl)benzoxazolinone or its N-methylated derivative provided eleven new 6-substituted aminoalkyl analogues. In a pharmacological evaluation, several compounds bearing an arylpiperazinic moiety were found to possess significant effects on arterial blood pressure and on the central nervous system; two of them showed interesting analgesic activity.

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