Coopersmith Ari S, Wolkowitz Owen M, Mellon Sindy H, Wu Gwyneth, Rampersaud Ryan, Hansen Nicholas, Dutcher Ethan G, Reus Victor I, Mayer Stefanie E
Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.
Department of OB-GYN and Reproductive Sciences, UCSF School of Medicine, San Francisco, CA, USA.
J Posit Psychol. 2024 Nov 14. doi: 10.1080/17439760.2024.2427577.
Positive psychology interventions have demonstrated efficacy in treating Major Depressive Disorder (MDD), but the relationship between dispositional optimism and antidepressant treatment response remains unclear. In this study, optimism (Revised Life Orientation Test, LOT-R) and depression severity (Hamilton Depression Rating Scale, HDRS) were assessed in healthy unmedicated MDD participants (N=86) and healthy controls (N=65). Treatment response (≥50% reduction in HDRS) was measured in 46 of these MDD participants after 8 weeks of open-label selective serotonin reuptake inhibitor (SSRI) treatment. MDD participants reported significantly lower pre-treatment optimism than healthy controls. Higher pre-treatment optimism, as well as greater increase in optimism (pre-treatment to 8 weeks), were associated with greater likelihood of being an SSRI responder versus non-responder (=0.21, =0.013; =0.32, =0.01, respectively), even when ratings of optimism/pessimism were excluded from depression severity/response ratings. The findings are consistent with the importance of aspects of positive psychology in treatment response. Possible mechanisms are discussed.
积极心理学干预已被证明在治疗重度抑郁症（MDD）方面有效，但特质乐观与抗抑郁治疗反应之间的关系仍不明确。在本研究中，对未接受药物治疗的健康MDD参与者（N = 86）和健康对照组（N = 65）进行了乐观程度（修订版生活取向测试，LOT-R）和抑郁严重程度（汉密尔顿抑郁量表，HDRS）评估。在这些MDD参与者中的46人接受了8周的开放标签选择性5-羟色胺再摄取抑制剂（SSRI）治疗后，测量了治疗反应（HDRS降低≥50%）。MDD参与者报告的治疗前乐观程度显著低于健康对照组。较高的治疗前乐观程度，以及乐观程度的更大增加（从治疗前到8周），与成为SSRI反应者而非无反应者的可能性更大相关（分别为= 0.21，= 0.013；= 0.32，= 0.01），即使在抑郁严重程度/反应评分中排除了乐观/悲观评分。这些发现与积极心理学方面在治疗反应中的重要性一致。讨论了可能的机制。
