Charles D, Larsen B
Gynecol Obstet Invest. 1985;20(4):194-8. doi: 10.1159/000298993.
Six women were given 1 g of piperacillin on the 2nd postpartum day and serum concentrations of the drug were measured at 0.5, 1, 2, and 4 h after infusion. The same women returned for an identical test 6 months later and hence served as their own controls. A second group of 6 women were treated identically except that they received the first dose of piperacillin on the 3rd postpartum day. The serum levels of antibiotic were consistently lower during the puerperium than at 6 months. The levels obtained at 2 compared to 3 days post partum were similar, but were about one half the levels obtained at 6 months post partum. These results indicate that antibiotic therapy for postpartum endomyometritis may need to take account of the fact that the altered pharmacokinetics of pregnancy persists into the puerperium. If used in this setting, the dose of piperacillin may need to be increased by 50% over the normal adult dose.
六名女性在产后第二天接受了1克哌拉西林治疗，并在输液后0.5、1、2和4小时测量了药物的血清浓度。相同的这六名女性在6个月后返回进行相同的测试，因此她们作为自己的对照。另一组6名女性接受了相同的治疗，只是她们在产后第三天接受了第一剂哌拉西林。产褥期抗生素的血清水平始终低于6个月时的水平。产后第2天与第3天获得的水平相似，但约为产后6个月时获得水平的一半。这些结果表明，产后子宫内膜炎的抗生素治疗可能需要考虑到妊娠期间改变的药代动力学持续到产褥期这一事实。如果在这种情况下使用，哌拉西林的剂量可能需要比正常成人剂量增加50%。
