Canturk Alp Omer, Senturk Adem
Department of General Surgery, Sakarya Training and Research Hospital, Sakarya, Turkey.
Department of Surgical Oncology, Sakarya Training and Research Hospital, Sakarya, Turkey.
Medicine (Baltimore). 2025 Aug 22;104(34):e44059. doi: 10.1097/MD.0000000000044059.
Third-space endoscopy (TSE) is a rapidly emerging field in gastrointestinal (GI) medicine that employs techniques such as endoscopic submucosal dissection (ESD), peroral endoscopic myotomy (POEM), and submucosal tunneling endoscopic resection. Despite TSE's expanding clinical applications and minimally invasive advantages of TSE, the global research landscape and collaborative networks that drive its evolution remain poorly defined.
A comprehensive search of the Web of Science Core Collection (WoSCC) was conducted for publications between 2015 and 2025 using predefined TSE-related keywords. Bibliometric indicators, including publication volume, citation analysis, geographic distribution, institutional and author productivity, and keyword co-occurrence networks, were assessed using VOSviewer and Microsoft Excel.
Of the initial 47,569 records, 6347 met our inclusion criteria. The number of publications per year has increased steadily from 2015 to 2025, indicating an intensification of academic and clinical interest in the TSE. Japan, the United States, and China were identified as the most prolific contributors, with leading institutions such as the Japan National Cancer Center and the Mayo Clinic. Europe has not been able to demonstrate a dominant scientific position in this field, and has lagged behind. "Surgical Endoscopy and Other Interventional Techniques" emerged as the journal with the highest number of articles published in the field of TSE. ESD and peroral endoscopic myotomy (POEM) are dominant research themes.
This bibliometric and visual analysis highlights the expanding role of TSE in modern gastrointestinal endoscopy. This underlines the clinical impact and research momentum. The predominance of Japanese and American institutions points to both geographical clustering of expertise and potential opportunities for wider international participation. Future perspectives should emphasize comparative clinical studies and rigorous long-term outcome studies to confirm the position of TSE as a cornerstone of minimally invasive GI treatment.
第三空间内镜检查（TSE）是胃肠（GI）医学中一个迅速兴起的领域，它采用诸如内镜黏膜下剥离术（ESD）、经口内镜肌切开术（POEM）和黏膜下隧道内镜切除术等技术。尽管TSE的临床应用不断扩大且具有微创优势，但其推动其发展的全球研究格局和合作网络仍未明确界定。
使用预定义的与TSE相关的关键词，对科学网核心合集（WoSCC）在2015年至2025年期间的出版物进行全面检索。使用VOSviewer和Microsoft Excel评估文献计量指标，包括出版量、引文分析、地理分布、机构和作者生产力以及关键词共现网络。
在最初的47569条记录中，6347条符合我们的纳入标准。从2015年到2025年，每年的出版物数量稳步增加，表明学术界和临床界对TSE的兴趣在增强。日本、美国和中国被确定为贡献最多的国家，领先机构包括日本国立癌症中心和梅奥诊所。欧洲在该领域未能展现出主导的科学地位，且已落后。《外科内镜与其他介入技术》成为TSE领域发表文章数量最多的期刊。ESD和经口内镜肌切开术（POEM）是主导研究主题。
这项文献计量和可视化分析突出了TSE在现代胃肠内镜检查中不断扩大的作用。这强调了临床影响和研究势头。日本和美国机构的主导地位既表明了专业知识的地理聚集，也指出了更广泛国际参与的潜在机会。未来的展望应强调比较临床研究和严格的长期结局研究，以确认TSE作为微创胃肠治疗基石的地位。
