Pariwatanasak Munchuporn, Chadarat Saowapa, Potiprapanpong Wisitsin, Kyopun Sukanya, Young Anne M, Panpisut Piyaphong
Faculty of Dentistry, Thammasat University, Pathum Thani, Thailand.
Department of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, Royal Free Hospital, Rowland Hill Street, London, UK.
Biomater Investig Dent. 2025 Aug 20;12:44551. doi: 10.2340/biid.v12.44551. eCollection 2025.
The development of ion-releasing resin composites is expected to reduce the risk of secondary caries. This study compared the degree of monomer conversion, biaxial flexural strength/modulus, elemental release, and remineralisation potential of a novel ion-releasing dental composite (Renewal MI) containing monocalcium phosphate monohydrate and polylysine.
The degree of monomer conversion after light curing for 20 s was determined ( = 8). The biaxial flexural strength and modulus after immersion in water for 24 h ( = 8) were evaluated. Additionally, the release of Ca and P after immersion in water for 2 weeks was assessed ( = 3). A disc specimen of the material ( = 1) was attached to the demineralised dentine and then immersed in simulated body fluid for 2 weeks to qualitatively determine mineral precipitation on dentine. The commercial comparison included Filtek Z350 XT, EQUIA Forte HT, FUJI VII, and FUJI II LC.
FUJI II LC demonstrated the highest degree of conversion (97.6%) compared to Renewal MI (57.2%) and Filtek Z350 XT (61.2%). The highest flexural strength was observed in Filtek Z350 XT (271 MPa), followed by MI (135 MPa), FUJI II LC (109 MPa), EQUIA Forte HT (50 MPa), and FUJI VII (35 MPa). The biaxial flexural modulus of Renewal MI (3.2 GPa) was comparable to that of EQUIA FORTE HT (3.8 GPa) and FUJI II LC (3.6 GPa). Ca and P release of MI (11 ppm, 45 ppm) was higher than that of FUJI VII (<0.1 ppm, 0.7 ppm). The precipitation of mineral precipitates in dentinal tubules of demineralised dentine was not detected in all materials.
Renewal MI demonstrated a degree of conversion similar to commercial resin composite but exhibited lower strength. However, its strength was much higher than conventional glass ionomer cements. The material promoted the high release of elements, which was expected to encourage the remineralising actions.
离子释放树脂复合材料的研发有望降低继发龋的风险。本研究比较了一种含一水磷酸二氢钙和聚赖氨酸的新型离子释放牙科复合材料（Renewal MI）的单体转化率、双轴弯曲强度/模量、元素释放和再矿化潜力。
测定光固化20秒后的单体转化率（n = 8）。评估在水中浸泡24小时后的双轴弯曲强度和模量（n = 8）。此外，评估在水中浸泡2周后钙和磷的释放情况（n = 3）。将该材料的圆盘试样（n = 1）附着在脱矿牙本质上，然后浸入模拟体液中2周，以定性确定牙本质上的矿物质沉淀。商业对照材料包括Filtek Z350 XT、EQUIA Forte HT、FUJI VII和FUJI II LC。
与Renewal MI（57.2%）和Filtek Z350 XT（61.2%）相比，FUJI II LC表现出最高的转化率（97.6%）。Filtek Z350 XT的弯曲强度最高（271 MPa），其次是MI（135 MPa）、FUJI II LC（109 MPa）、EQUIA Forte HT（50 MPa）和FUJI VII（35 MPa）。Renewal MI的双轴弯曲模量（3.2 GPa）与EQUIA FORTE HT（3.8 GPa）和FUJI II LC（3.6 GPa）相当。MI的钙和磷释放量（11 ppm，45 ppm）高于FUJI VII（<0.1 ppm，0.7 ppm）。在所有材料中均未检测到脱矿牙本质的牙本质小管中有矿物质沉淀。
Renewal MI的转化率与商业树脂复合材料相似，但强度较低。然而，其强度远高于传统玻璃离子水门汀。该材料促进了元素的高释放，有望促进再矿化作用。
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