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一名青春期女孩感染新冠病毒后发生的免疫球蛋白A血管炎

Immunoglobulin A Vasculitis Following COVID-19 Infection in an Adolescent Girl.

作者信息

Atris Ahmed, Al Salmi Issa, Al Balushi Abeer, Al Abri Seif

机构信息

Department of Renal Medicine, Royal Hospital, Muscat, Oman.

Department of Dermatology, Al Nahdha Hospital, Muscat, Oman.

出版信息

Oman Med J. 2025 Mar 31;40(2):e740. doi: 10.5001/omj.2025.09. eCollection 2025 Mar.

Abstract

Immunoglobulin A vasculitis, formerly known as Henoch-Schoenlein purpura, is a rare acute auto-immune condition often associated with infections. We describe an adolescent girl who had recently recovered from COVID-19 infection. She presented with painless hematuria, high blood pressure, purpuric skin rash, bilateral ankle pain and swelling, abdominal pain, and inability to walk. She was admitted and clinically diagnosed with immunoglobulin A vasculitis and started on steroid treatment, to which there was a dramatic response, only to relapse as the steroid was being tapered off. Treatment with azathioprine as a steroid-sparing agent led to complete remission without recurrence. This case also suggests that SARS-CoV-2 infection may trigger the development of autoimmune diseases.

摘要

免疫球蛋白A血管炎,以前称为过敏性紫癜,是一种罕见的急性自身免疫性疾病,常与感染有关。我们描述了一名刚从新冠病毒感染中康复的青春期女孩。她出现无痛性血尿、高血压、紫癜性皮疹、双侧踝关节疼痛和肿胀、腹痛以及无法行走。她入院后临床诊断为免疫球蛋白A血管炎,并开始使用类固醇治疗,对此有显著反应,但在类固醇减量时复发。使用硫唑嘌呤作为类固醇替代药物进行治疗导致完全缓解且无复发。该病例还表明,新冠病毒感染可能触发自身免疫性疾病的发生。

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A Child with COVID-19 and Immunoglobulin A Vasculitis.儿童 COVID-19 合并免疫球蛋白 A 血管炎。
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