Gulyayev Alexandr E, Absattarova Karlygash S, Kairgeldina Sayagul A, Dosmagambetova Raushan S, Tekebayev Kanat K, Baurzhan Madina B, Sagandykova Nazym, Dauletova Gaukhar Sh
Scientific Research Department, Ministry of Health of the Republic of Kazakhstan, Research Institute of Balneology and Medical Rehabilitation, Astana 010000, Kazakhstan.
Laboratory of Drug Discovery and Development, Nazarbayev University, Astana 010000, Kazakhstan.
Adv Respir Med. 2025 Aug 13;93(4):30. doi: 10.3390/arm93040030.
Occupational bronchopulmonary diseases (OBPDs)-including pneumoconiosis, silicosis, and occupational COPD-remain a pressing public health issue, especially in regions with intensive mining, metallurgy, and construction industries. Caused by chronic inhalation of fibrogenic dusts, these conditions are often diagnosed at late stages, resulting in irreversible lung damage and diminished work capacity.
A scoping review was performed using the Arksey and O'Malley framework, with methodological refinements from the Joanna Briggs Institute. Following PRISMA-ScR guidelines, we searched PubMed, Scopus, and gray literature for publications from 2014 to 2024. After screening 1761 records and full-text review, nine studies were included in the final synthesis, comprising two systematic reviews, two narrative literature reviews, and five observational studies.
Key risk factors identified included prolonged exposure to silica and coal dust, tobacco use, and genetic susceptibility. Diagnostic delays were attributed to the underuse of high-resolution CT and exhaled nitric oxide analysis. Several studies highlighted the diagnostic value of oxidative stress and inflammatory markers (e.g., IL-6, TNF-α). Nutritional rehabilitation and polyphenol-enriched herbal therapies were associated with improved respiratory function and quality of life. However, these strategies remain underutilized, particularly in low-resource settings.
A coordinated, biomarker-driven approach integrating early diagnosis, dust exposure control, and tailored rehabilitation is urgently needed. Multidisciplinary models may reduce the clinical and socioeconomic burden of OBPDs.
职业性支气管肺部疾病(OBPDs)——包括尘肺病、矽肺病和职业性慢性阻塞性肺疾病(COPD)——仍然是一个紧迫的公共卫生问题,尤其是在采矿、冶金和建筑行业密集的地区。这些疾病由长期吸入致纤维化粉尘引起,往往在晚期才被诊断出来,导致不可逆转的肺损伤和工作能力下降。
采用阿克斯西和奥马利框架进行了一项范围综述,并采用了乔安娜·布里格斯研究所的方法改进。遵循PRISMA-ScR指南,我们在PubMed、Scopus和灰色文献中搜索了2014年至2024年的出版物。在筛选了1761条记录并进行全文审查后,最终综合纳入了9项研究,包括两项系统评价、两项叙述性文献综述和五项观察性研究。
确定的主要风险因素包括长期接触二氧化硅和煤尘、吸烟和遗传易感性。诊断延迟归因于高分辨率CT和呼出一氧化氮分析的使用不足。几项研究强调了氧化应激和炎症标志物(如IL-6、TNF-α)的诊断价值。营养康复和富含多酚的草药疗法与呼吸功能和生活质量的改善有关。然而,这些策略的利用率仍然很低,尤其是在资源匮乏的环境中。
迫切需要一种协调的、以生物标志物为驱动的方法,将早期诊断、粉尘接触控制和个性化康复结合起来。多学科模式可能会减轻职业性支气管肺部疾病的临床和社会经济负担。