Mrabet Wissal, Karrat Abdelhafid, Amine Aziz
Laboratory of Process Engineering and Environment, Faculty of Sciences and Techniques, Hassan II University of Casablanca, P.A. 146, Mohammedia 28806, Morocco.
Biosensors (Basel). 2025 Aug 13;15(8):529. doi: 10.3390/bios15080529.
The demand for rapid, energy-efficient, and low-toxicity methods for synthesizing molecularly imprinted polymers (MIPs) is increasing, particularly for applications in environmental monitoring and green chemistry. In this context, the present work focuses on the development of a novel laser-assisted method for MIP synthesis, employing a visible laser (450 nm) and erythrosine B as a green photoinitiator. This visible-light approach enables fast and spatially controlled polymerization while avoiding the drawbacks of conventional methods (thermal heating, UV synthesis), such as the use of toxic initiators like AIBN and the need for UV shielding. MIPs were synthesized for bisphenol A and sulfamethoxazole, two emerging contaminants of significant environmental concern. The synthesis process was optimized for rapidity and scalability, and the resulting MIPs were integrated into a paper-based analytical device (MIP-PAD) for smartphone-assisted, on-site detection. The developed sensors exhibited excellent analytical performance, with recovery rates of 98.6% in tap water and 90.2% in river water and relative standard deviations (RSDs) below 1.88%. This study demonstrated a green, efficient, and highly controllable laser-assisted polymerization technique, offering a promising alternative to conventional MIP synthesis methods.
对于合成分子印迹聚合物（MIP）的快速、节能且低毒方法的需求日益增长，尤其是在环境监测和绿色化学领域的应用。在此背景下，本工作聚焦于开发一种用于MIP合成的新型激光辅助方法，采用可见光激光（450纳米）和赤藓红B作为绿色光引发剂。这种可见光方法能够实现快速且空间可控的聚合反应，同时避免了传统方法（热加热、紫外光合成）的缺点，例如使用像偶氮二异丁腈这样的有毒引发剂以及对紫外线屏蔽的需求。针对双酚A和磺胺甲恶唑这两种备受环境关注的新兴污染物合成了MIP。对合成过程进行了快速性和可扩展性的优化，并将所得的MIP集成到用于智能手机辅助现场检测的纸质分析装置（MIP-PAD）中。所开发的传感器展现出优异的分析性能，在自来水中的回收率为98.6%，在河水中为90.2%，相对标准偏差（RSD）低于1.88%。本研究展示了一种绿色、高效且高度可控的激光辅助聚合技术，为传统MIP合成方法提供了一种有前景的替代方案。
