Polidori M Cristina
Klinik II für Innere Medizin, Medizinische Fakultät und Uniklinik Köln, Universität zu Köln, Köln, Deutschland.
Exzellenzcluster CECAD, Universität zu Köln, Köln, Deutschland.
Inn Med (Heidelb). 2025 Aug 27. doi: 10.1007/s00108-025-01982-6.
Frailty is an established clinical syndrome that occurs more frequently with increasing age, but also often contributes to irreversible functional loss in younger adults. Its multidimensional, complex pathophysiology and phenotypic nature is associated with atypical disease presentation and underdiagnosis in clinical routine. The latter still utilizes, especially in nongeriatric settings, medical technologies that are often unable to capture and measure frailty. In addition, frailty progresses per se rather imperceptibly until its late stages, when it is too close to the point of no return and difficult to treat efficiently. Therefore, prevention of frailty is key in the context demographic change, characterized by socioeconomically unsustainable rates of multimorbidity and disability. In the framework of the present special issue, this contribution aims at highlighting relevance, potential, and methodology of frailty prevention for the maintenance of function and vitality during life.
衰弱是一种既定的临床综合征，随着年龄增长更为常见，但在年轻人中也常常导致不可逆的功能丧失。其多维、复杂的病理生理学和表型特征与临床常规中非典型的疾病表现和诊断不足有关。后者，尤其是在非老年环境中，仍在使用往往无法捕捉和测量衰弱的医疗技术。此外，衰弱本身进展相当隐匿，直到晚期才被察觉，而此时已接近无法挽回的地步且难以有效治疗。因此，在以多重疾病和残疾的社会经济不可持续发生率为特征的人口结构变化背景下，预防衰弱是关键。在本期特刊的框架内，本论文旨在强调预防衰弱对于维持生活中的功能和活力的相关性、潜力及方法。
