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[预防衰弱]

[Prevention of frailty].

作者信息

Eidam Annette, Bauer Jürgen M, Benzinger Petra

机构信息

Geriatrisches Zentrum am Universitätsklinikum Heidelberg, AGAPLESION Bethanien Krankenhaus, Rohrbacher Str. 149, 69126, Heidelberg, Deutschland.

Hochschule für angewandte Wissenschaften, Institut für Gesundheit und Generationen, Bahnhofstraße 61, 87435, Kempten, Deutschland.

出版信息

Z Gerontol Geriatr. 2024 Oct;57(6):435-441. doi: 10.1007/s00391-024-02353-w. Epub 2024 Sep 18.

DOI:10.1007/s00391-024-02353-w
PMID:39292238
Abstract

BACKGROUND

The presence of frailty in older patients increases the risk for adverse health events and for a loss of independence. Measures for the prevention of this geriatric syndrome should be incorporated into routine healthcare.

OBJECTIVE

What types of interventions could be effective in the prevention of frailty and how can preventive strategies be successfully implemented?

METHOD

Narrative review article.

RESULTS

The concept of frailty is multidimensional and potential starting points for a prevention of frailty can be found within different dimensions (e.g., dimensions of physical activity and nutrition, psychosocial dimension). Epidemiological analyses have identified factors that increase or decrease the risk for becoming frail. Evidence from randomized controlled trials that examined the effectiveness of specific interventions in the prevention of frailty is still limited. Based on the available data, interventions using physical exercise appear to be effective in preventing frailty. In primary care in Germany the frailty status of older patients is not yet routinely recorded, which impedes the identification of patients at risk (patients with pre-frailty) and the implementation of targeted preventive strategies. The Integrated Care for Older People (ICOPE) concept of the World Health Organization offers a potential approach to prevent frailty and to promote healthy ageing within the population.

CONCLUSION

The prevention of frailty is possible and reasonable. Comprehensive and targeted preventive strategies are yet to be implemented.

摘要

背景

老年患者虚弱的存在会增加不良健康事件和失去独立生活能力的风险。预防这种老年综合征的措施应纳入常规医疗保健中。

目的

哪些类型的干预措施对预防虚弱有效,以及如何成功实施预防策略?

方法

叙述性综述文章。

结果

虚弱的概念是多维度的,预防虚弱的潜在起点可以在不同维度中找到(例如,身体活动和营养维度、心理社会维度)。流行病学分析已经确定了增加或降低虚弱风险的因素。关于特定干预措施预防虚弱有效性的随机对照试验证据仍然有限。根据现有数据,体育锻炼干预似乎对预防虚弱有效。在德国的初级保健中,老年患者的虚弱状况尚未常规记录,这阻碍了对有风险患者(虚弱前期患者)的识别以及有针对性预防策略的实施。世界卫生组织的老年人综合照护(ICOPE)概念为预防虚弱和促进人群健康老龄化提供了一种潜在方法。

结论

预防虚弱是可行且合理的。全面且有针对性的预防策略尚未得到实施。

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引用本文的文献

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[Preventing frailty and maintaining good health during aging].[预防衰老过程中的虚弱并保持良好健康状态]
Inn Med (Heidelb). 2025 Aug 27. doi: 10.1007/s00108-025-01982-6.

本文引用的文献

1
Recent developments in frailty identification, management, risk factors and prevention: A narrative review of leading journals in geriatrics and gerontology.衰弱识别、管理、风险因素及预防的最新进展:老年医学与老年学领域主要期刊的叙述性综述
Ageing Res Rev. 2023 Nov;91:102082. doi: 10.1016/j.arr.2023.102082. Epub 2023 Oct 4.
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Comparison of the Risk Analysis Index and the modified 5-factor frailty index in predicting 30-day morbidity and mortality after spine surgery.比较风险分析指数和改良的 5 因素衰弱指数预测脊柱手术后 30 天发病率和死亡率。
J Neurosurg Spine. 2023 Apr 7;39(1):136-145. doi: 10.3171/2023.2.SPINE221019. Print 2023 Jul 1.
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Frailty and Cancer: Current Perspectives on Assessment and Monitoring.
虚弱与癌症:评估和监测的当前观点。
Clin Interv Aging. 2023 Mar 28;18:505-521. doi: 10.2147/CIA.S365494. eCollection 2023.
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Effects of Vitamin D, Omega-3 Fatty Acids and a Home Exercise Program on Prevention of Pre-Frailty in Older Adults: The DO-HEALTH Randomized Clinical Trial.维生素 D、欧米伽 3 脂肪酸和家庭运动方案对预防老年人衰弱前期的影响:DO-HEALTH 随机临床试验。
J Frailty Aging. 2023;12(1):71-77. doi: 10.14283/jfa.2022.48.
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Frailty: A Multidimensional Biopsychosocial Syndrome.衰弱:一种多维生物心理社会综合征。
Med Clin North Am. 2023 Jan;107(1):183-197. doi: 10.1016/j.mcna.2022.04.006. Epub 2022 Oct 28.
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Effect of Vitamin D3 and Omega-3 Fatty Acid Supplementation on Risk of Frailty: An Ancillary Study of a Randomized Clinical Trial.维生素 D3 和欧米伽 3 脂肪酸补充剂对虚弱风险的影响:一项随机临床试验的辅助研究。
JAMA Netw Open. 2022 Sep 1;5(9):e2231206. doi: 10.1001/jamanetworkopen.2022.31206.
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Implementation of the WHO integrated care for older people (ICOPE) programme in clinical practice: a prospective study.WHO 老年人综合关怀(ICOPE)方案在临床实践中的实施:一项前瞻性研究。
Lancet Healthy Longev. 2022 Jun;3(6):e394-e404. doi: 10.1016/S2666-7568(22)00097-6. Epub 2022 Jun 9.
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Long-Term Effects on Preventing Frailty and Health Care Costs Associated with a Multifactorial Intervention in the Elderly: Three-Year Follow-Up Data from the Pre-Frail 80 Study.多因素干预对预防老年人衰弱和医疗保健费用的长期影响:脆弱前期 80 岁研究的三年随访数据。
Gerontology. 2022;68(10):1121-1131. doi: 10.1159/000521497. Epub 2022 Feb 4.
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The Effect of Low-Dose Aspirin on Frailty Phenotype and Frailty Index in Community-Dwelling Older Adults in the ASPirin in Reducing Events in the Elderly Study.阿司匹林减少老年人事件研究中社区居住的老年人低剂量阿司匹林对虚弱表型和虚弱指数的影响。
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Frailty in cardiology: definition, assessment and clinical implications for general cardiology. A consensus document of the Council for Cardiology Practice (CCP), Association for Acute Cardio Vascular Care (ACVC), Association of Cardiovascular Nursing and Allied Professions (ACNAP), European Association of Preventive Cardiology (EAPC), European Heart Rhythm Association (EHRA), Council on Valvular Heart Diseases (VHD), Council on Hypertension (CHT), Council of Cardio-Oncology (CCO), Working Group (WG) Aorta and Peripheral Vascular Diseases, WG e-Cardiology, WG Thrombosis, of the European Society of Cardiology, European Primary Care Cardiology Society (EPCCS).心血管领域的脆弱性:定义、评估及对普通心血管病学的临床意义。该共识文件由欧洲心脏病学会(ESC)下属的心血管病实践委员会(CCP)、急性心血管护理协会(ACVC)、心血管护理和相关专业协会(ACNAP)、欧洲预防心脏病学会(EAPC)、欧洲心律协会(EHRA)、瓣膜心脏病学会(VHD)、高血压学会(CHT)、心血管肿瘤学会(CCO)、工作组(WG)主动脉和外周血管疾病、WG 电子心脏病学、WG 血栓形成,以及欧洲初级保健心脏病学会(EPCCS)共同制定。
Eur J Prev Cardiol. 2022 Feb 19;29(1):216-227. doi: 10.1093/eurjpc/zwaa167.