Convergence: Multi-omics and AI are reshaping the landscape biomedical research.

This special volume of Biochimica et Biophysica Acta - Molecular Basis of Disease showcases a transformative era in biomedical research, driven by the convergence of multi-omics technologies, artificial intelligence (AI), and systems biology. The volume is focused across eight thematic sections-spanning cancer, inflammatory and infectious diseases, neurodegeneration, cardiovascular health, autophagy, respiratory disease, and heme biology-this volume highlights how integrative methodologies are helping to simplify the complexity of disease mechanisms. These studies discuss not only biomarker discovery and disease mechanisms, but also how redox biology, lipidomics, machine learning, and proteogenomics are redefining pathophysiological frameworks. From spatial omics in colorectal cancer to ferroptosis in asthma and sepsis, these contributions demonstrate the translational power of different network analysis and validations. Key challenges-including standardization, ethical integration of AI, and global infrastructure gaps-are also addressed as future imperatives. Together, the articles in this volume serve not just as a repository of high-impact findings, but as an example of the roadmap toward precision medicine where diagnostics, therapies, and prognoses are tailored to the molecular individuality of each patient. This collection establishes BBA - Molecular Basis of Disease as a leading platform for next-generation disease biology and personalized healthcare innovation.